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References in periodicals archive ?
In DILE involving antiepileptic drugs, the few reported cases of renal involvement have been associated mainly with ethosuximide (41).
Ethosuximide is a voltage-dependent T-type [Ca.sup.+2] channel blocker, or rather, the anticonvulsant of choice in the treatment of absence epilepsy (COULTER et al., 1989; MACDONALD; MCLEAN, 1986; MANNING et al., 2003).
Dickenson, "Effects of ethosuximide, a T-type [Ca.sup.2+] channel blocker, on dorsal horn neuronal responses in rats," European Journal of Pharmacology, vol.
demonstrated that fibroblast growth factor (FGF) and ethosuximide, which is used clinically to treat absence seizures in humans, induced neuronal differentiation of muscle-derived stem cells by showing immunohistochemically positive cells for TuJ1, NeuN, and neurofilaments M and H[150].
Ethosuximide is the drug of choice but not available in Pakistan.
Other anticonvulsants associated with overgrowth are carbamazepine, primidone, phenobarbital, ethosuximide, methosuximide, valproic acid.
Drugs implicated in forced normalisation Ethosuximide (18) Lamotrigine (26) Vigabatrin (26) Levetiracetam (28) Topiramate (29) Table II.
The individual anti-epileptic drugs studied included carbamazepine, clonazepam, ethosuximide, gabapentin, phenobarbital, phenytoin and valproic acid.
For her epilepsy, Blisse has to take 1,000mg of Vigabatrin, 300mg of Rufinamide, 60mg of Lamotrigine and 250mg of Ethosuximide. She also usually needs three or four doses a week of Midazolam - used to bring her out of seizures.
Self-harming or suicidal behaviors were not significantly associated with barbiturate AEDs (phenobarbital, primidone, and methylphenobarbital), conventional AEDs (carbamazepine, valproate, pheny-toin, ethosuximide, and acetazolamide), or newer AEDs that do not carry an increased risk of depression (ox-carbazepine, lamotrigine, gabapentin, or pregabalin).
The companies' combined strengths in such other drugs as tetracycline (nearly 99% of the market between them); ethosuximide (about 88%); and metronidazole (82%) could also present problems, analysts say.
Effects of anticonvulsants on learning: Performance of pigeons under a repeated acquisition procedure when exposed to phenobarbital, clonazepam, valproic acid, ethosuximide and phenytoin.