deficiency disorder is a rare hematological disorder inherited in an autosomal recessive manner.
deficiency diagnosed following use of adalimumab.
Kindred with combined factor XI
and factor IX deficiency have been described.
People who are deficient in Factor XI
have a lower incidence of thromboembolic events with minimal increase in bleeding risk.
Interestingly, in contrast to hemophilia a and b, which are associated with mutations on the X chromosome, factor xi
deficiency is linked to gene mutations on chromosome 4, an autosome.
Rare inherited coagulation disorders in Southern Iran include factor X, factor VII, factor XIII, factor I and factor XI
deficiency in the descending order of frequency whereas from India it is factor X deficiency followed by factor XIII, I, VII and V in the same order.15,16 The non sex linked bleeding disorders also demonstrate a slight male predominance.
The generated FXIIa can initiate activation of factor XI
and also seems to participate in the conversion of plasminogen to plasmin [6,7].
AF253319), choriogenin 2 (E = 1e-45), choriogenin 3 (E = 4e-43), coagulation factor XI
(E = 3e-12), ER[alpha] (E = 1e-71), glycosylate reductase (E = 3e-14), hepatic lipase precursor (E = 7e-6), 3-hydroxy-3-methylglutaryl-coenzyme A (CoA) reductase (E = 9e-51), low-molecular-mass protein 2 (E = 2e-12), transferrin (E = 8e-26), ubiquitin-conjugating enzyme 9 (the cDNA clone is 87% identical at the 5' end to an EST clone (GenBank accession no.
One of them, factor XI
, contributes to the formation of the enzyme thrombin, which in turn helps make a protein called fibrin, a key clotting agent in the blood.
As part of this launch, Novartis (NVS) has licensed to Anthos MAA868, an antibody directed at Factor XI
and XIa, key components of the intrinsic coagulation pathway.
can be used in the quantification of Factor VI, Factor VII, Factor VII, Factor IX, and Factor XI