(redirected from gap junctional intercellular communication)
GJICgap junctional intercellular communication
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Effective reduction of neuronal death by inhibiting gap junctional intercellular communication in a rodent model of global transient cerebral ischemia.
Assay Biological functions represented Induction of cytochrome P450 enzymes Receptor-mediated activity (Ah receptor) Activation of mitogen-activated protein kinases Intracellular signaling Disruption of gap junctional intercellular communication Intercellular signaling, cell death Activation of AP-1 transcription factor Gene expression Alteration in neutrophil function Cellular function, cell death Stimulation of insulin release Cellular function Contraction of uterine muscle in vitro Integrated tissue function Alteration in fertilization in vitro Integrated tissue/organ system function Stimulation of lymphocyte Proliferation, cell death proliferation Table 2.
The SAR models for eye irritation (47), sensory irritation (48), developmental toxicity in humans (49) and in hamsters (50), allergic contact dermatitis (51), inhibition of gap junctional intercellular communication (GJIC) (52), and environmental biodegradation (53) were also used.