Neurogenic locus notch homolog protein (NOTCH), nitric oxide synthetase (NOS), soluble guanylate cyclase (sGC), Cyclic guanosine monophosphate (cGMP), tryptophan hydroxylase 1 (TPH 1), serotonin type 2B receptor (5HT2BR), phospholipase C (PLC), extracellular-signal regulated kinase (ERK), transforming growth factor [beta] (TGF[beta]), Receptor I (RI), Receptor II (RII), mother against decantaplegic homolog (Smad), smooth muscle actin ([alpha] SMA), non-muscle embryonic myosin (Smemb), glycosaminoglycan
(GAG), proteoglycan (PG), matrix metalloproteinases (MMPs).
TGF-beta stimulates biglycan core protein synthesis but not glycosaminoglycan
chain elongation via Akt phosphorylation in vascular smooth muscle.
Other research-backed ingredients often added to formulations for sports-related joint support include bone health ingredients such as calcium and vitamin D, as well as omega-3 fatty acids and glycosaminoglycans
, especially chondroitin sulfate.
Prediction of glycosaminoglycan
content in human cartilage by age, T1n and T2 MRI.
Nair, "Biomimetic fiber assembled gradient hydrogel to engineer glycosaminoglycan
enriched and mineralized cartilage: An in vitro study," Journal of Biomedical Materials Research Part A, vol.
Studies on the link between glycosaminoglycan
and CAD were limited in the last decades.
(a) Upper panels show glycosaminoglycan
(GAG) expression by Alcian blue staining; lower panels show COL II expression by immunohistochemistry.
With regard to the glycosaminoglycan
moiety of UTI, CS levels, expressed as [micro]g UA/mg creatinine, were found significantly higher in both T1DM and T2DM patients with respect to controls (p = 0.005 and p = 0.041, resp.).
There is an effective injectable polysulfated glycosaminoglycan
, Adequan, available through your veterinarian.
Lysosomal storage disorders (LSDs) (4) are genetic diseases caused by deficiencies of activities of enzymes that degrade substrates including glycolipids, glycosaminoglycans
, and proteins (1).
Homozygous missense mutations in B3GAT3 have previously been described as "linkeropathies." Glycosaminoglycan
linkeropathies are characterised by their enzymatic inability to synthesise the common linker region, which joins the core protein with its respective glycosaminoglycan
side chain .
and versican deposits in taxane-induced sclerosis," British Journal of Dermatology, vol.