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Serum hK2, hK3, hK5, hK6, hK7, hK8, hK10, and hK11 concentrations were significantly (P <0.05) up-regulated by testosterone treatment, with the most profound impact on hK3 and hK2.
This hormonal intervention produced a significant up-regulation of serum hK2, hK3, hK5, hK6, hK7, and hK10 concentrations, with the most profound impact on hK2 and hK3.
Slolopass HK10 is part of a complete portfolio of zinc/zinc alloy processes and advanced passivats and topcoats.
Serum hK6 and hK10 concentrations were also suppressed by both treatments but to a much lesser degree.
We found significant correlations between serum concentrations of hK2 and hK3 (positive) or hK10 (negative), between hK4 and hK13 or hK14 (both positive), between hK5 and hK6 (positive), and between hK7 and hK8, hK13, or hK14 (all positive).
Together with the interim dividend of HK10 cents per share, total dividend for 2014 amounted to HK25 cents per share (2013 same period: HK25 cents per share).
hK10 protein was also shown to be produced in many tissues (17), but this protease has not yet been shown to have enzymatic activity (25).
Recombinant hK1, hK2, hK3, hK4, hK5, hK6, hK7, hK8, hK9, hK10, hK11, hK12, hK14, and hK15 proteins did not produce measurable readings, even at concentrations 1000-fold higher than that of hK13.
Because the KLK8 gene is predicted to encode for a secreted serine protease, this enzyme may have value as a biomarker, similar to hK3 (PSA) (3), hK6, hK10 (NES1), and hK11 (TLSP) (4-7).
The cross-reactivity of our assay with other kallikreins was determined by the use of purified, recombinant hK2 (250 [micro]g/L), hK3 (PSA; 1000 [micro]g/L), hK5 (1000 [micro]g/L), hK6 (2500 [micro]g/L), hK7 (1000 [micro]g/L), hK8 (1000 [micro]g/L), hK9 (1000 [micro]g/L), hK10 (1000 [micro]g/L), hK11 (1000 [micro]g/L), hK12 (1000 [micro]g/L), hK13 (1000 [micro]g/L), and hK14 (1000 [micro]g/L).
With the new nomenclature, which will be used throughout this report, NES1 is designated as KLK10 and the encoded protein as hK10. KLK10 was isolated with subtractive hybridization, by virtue of its down-regulation in radiation-transformed breast epithelial cells (8).
New gene Previous gene New protein symbol (a,b) symbol(s) symbol KLK1 KLK1 hK1 KLK3 KLK3 hK3 KLK2 KLK2 hK2 KLK4 PRSS17, KLK-L1, KLK4 hK4 KLK5 KLK-L2 hK5 KLK6 PRSS9 hK6 KLK7 PRSS6 hK7 KLKS PRSS19 hK8 KLK9 KLK-L3 hK9 KLK10 PRSSL1, hK10 KLK11 PRSS20 hK11 KLK12 KLK-L5 hK12 KLK13 KLK-L4 hK13 KLK14 KLK-L6 hK14 New gene symbol (a,b) Other protein names/symbols KLK1 Pancreatic/renal kallikrein, hPRK KLK3 Prostate-specific antigen, PSA KLK2 Human glandular kallikrein 1, hGK-1 KLK4 Prostase, KLK-L1 protein, EMSP1 KLK5 KLK-L2 protein, HSCTE KLK6 Zyme, protease M, neurosin KLK7 HSCCE KLKS Neuropsin, ovasin, TADG-14 KLK9 KLK-L3 protein KLK10 NES1 protein KLK11 TLSP/hippostasin KLK12 KLK-L5 protein KLK13 KLK-L4 protein KLK14 KLK-L6 protein New gene GenBank symbol (a,b) Accession No.
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