Furthermore, this assay appears to be very specific: we did not observe any detectable cross-reactivities with the highly homologous kallikrein proteins PSA (hK3), hK2, and hK6
This is in contrast to some other kallikreins, most prominently hK6
(protease M/neurosin), which is highly expressed in human brain and is present at very high concentrations in cerebrospinal fluid (22, 23).
TOTAL PROTEIN, hK5, AND hK6
CONCENTRATIONS IN ROLLER BOTTLE CULTURE OVER TIME
Preliminary studies have indicated that hK6
enhances the detection capability of the approved ovarian cancer assay CA-125," said Paul Baehr, IBEX President and CEO.
Serum hK2, hK3, hK5, hK6
, hK7, hK8, hK10, and hK11 concentrations were significantly (P <0.
and hK10 concentrations were also suppressed by both treatments but to a much lesser degree.
We are focused on establishing hK10 and hK6
as complementary assays to CA125, the standard biomarker for ovarian cancer.
The Board has proposed an interim dividend of HK6
cents per ordinary share and a bonus issue of two bonus shares for every 10 existing ordinary shares held.
Other members of the family (hK2, hK6
, and hK10) are emerging tumor markers for prostate, ovarian, and breast cancer (6, 7).
She was the first to purify and functionally characterize hK6
and hK10 from ovarian cancer ascites fluid and hK11, a candidate prostate cancer biomarker, from seminal plasma.
Recently, four other members of the human kallikrein family, hK5, hK6
(neurosin), hK10 (normal epithelial cell specific 1), and hK11 (trypsin-like serine protease), were found to be potential serum biomarkers for breast, ovarian, and prostate cancer (10-13).
The human kallikrein 6 (KLK6) gene, which encodes for hK6
protein, was cloned independently by three groups.