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Membranes were washed in TBST and probed with polyclonal anti-hK5 (1:2000) and hK6 (1:3000) primary antibodies for 1 h in 5% milk in TBST.
Serum hK2, hK3, hK5, hK6, hK7, hK8, hK10, and hK11 concentrations were significantly (P <0.05) up-regulated by testosterone treatment, with the most profound impact on hK3 and hK2.
Serum hK6 and hK10 concentrations were also suppressed by both treatments but to a much lesser degree.
Other members of the family (hK2, hK6, and hK10) are emerging tumor markers for prostate, ovarian, and breast cancer (6, 7).
- Recommended the payment of an interim dividend of HK6 cents per share
She was the first to purify and functionally characterize hK6 and hK10 from ovarian cancer ascites fluid and hK11, a candidate prostate cancer biomarker, from seminal plasma.
Excluding the increase in the fair value of investment properties, the Company's core operating profit increased 83.4% to HK$436 million (30 June 2015: HK$237 million) with core EPS increased 72.6% to HK6.92 cents per share (30 June 2015: HK4.01 cents).
Recently, four other members of the human kallikrein family, hK5, hK6 (neurosin), hK10 (normal epithelial cell specific 1), and hK11 (trypsin-like serine protease), were found to be potential serum biomarkers for breast, ovarian, and prostate cancer (10-13).
- Interim dividend of HK6.0 cents per ordinary share
The human kallikrein 6 (KLK6) gene, which encodes for hK6 protein, was cloned independently by three groups.
Basic earnings per share for the Period was HK8.6 cents (1H2014: HK6.4 cents).
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