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This study was performed to estimate the prevalence of HMPV in patients with community-acquired lower respiratory tract infection in Upper Egypt, and more important, to give new insights into circulating HMPV strains in Egypt at all.
* Comment: In addition to hMPV, the panel detects adenovirus, influenza A (nonspecific subtype), influenza A H1, influenza A H3, influenza B, respiratory syncytial virus (RSV) A, RSV B, rhinovirus, and parainfluenza 1, 2, and 3, according to Luminex.
* Comment: In addition to hMPV, the panel detects adenovirus, influenza A (nonspecific subtype), influenza A (H1), influenza A (H3), influenza B, respiratory syncytial virus (RSV) A, RSV B, rhinovirus, and parainfluenza 1, 2, and 3.
It is a combination vaccine that consists of two distinct mRNA sequences encoding the fusion (F) proteins of hMPV and PIV3 formulated in Moderna's proprietary lipid nanoparticle technology.
Clinical characteristics such as host immunity in patients with HMPV infection and radiologic findings of HMPV pneumonia are needed for early detection of HMPV infection and for studies of HMPV pneumoniarelated outcomes (14,20,21).
For example, although AdV and RV circulate all year, flu, hMPV, PIV, and RSV have a winter seasonal peak.
All samples were tested with Infiniti RVP plus assay on Infiniti Plus analyzer which identifies the following respiratory viruses: Influenza A virus (FluA), Influenza B virus (FluB), Influenza A-Swine H1N1 virus, hPIV (1,2,3, and 4), hRV (A and B), EV (A , B , C, and D), hCoV (HKU1 , OC43 , NL63, and 229E), hMPV (A and B), hRSV (A and B), and hAdv (A, B, C, and D) with 90% sensitivity and 100 specificity according to manufacturer (AutoGenomics, USA).
hMPV has been reported in up to 19% of hospitalised SA children with respiratory tract infections (RTIs).
RT-PCR methods were applied to test RNA of RV and hMPV, and DNA of HBoV.
In addition, 36 of the HPIV positive NPAs were co-detected with other viral pathogens determined by the DFA, including 8 positive for HPIV1 (6 RSV, 1 FluA, and 1 HAdV), 27 positive for HPIV3 (16 RSV, 7 HAdV, 2 HMPV, 1 FluB, and 1 FluA), and 1 positive for three pathogens (HPIV3, RSV, and FluB).
Between 2010 and 2012, influenza A and B, RSV, adenovirus and PIV type 1-3 were investigated in 148 samples using Shell vial cell culture and PIV type 4, hMPV, rhinovirus, coronavirus and bocavirus were investigated using multiplex PCR test.
hMPV was detected in six of nine specimens; no other pathogens were detected.
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