hNPCsHuman Neural Progenitor Cells
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The quantification data pertain to transcriptomics data on the human proteins expressed by skin [17] and hNPCs cells [56] upon ZIKV infection.
Additionally, information relative to the fold change is annotated for skin and hNPCs when available [17, 56].
The integration of fold change data in skin and hNPCs in Figure 2 allows the evaluation of the pathways which may occur in these two cell types during ZIKV infection.
RESULTS: In contrast to wild-type mNPCs, hNPCs and AhR-deficient mNPCs were insensitive to AhR agonism or antagonism.
CONCLUSION: Our findings suggest that in contrast to wild-type mNPCs, hNPCs were protected against polycyclic aromatic hydrocarbon-induced DNT because of an absence of AhR.
To investigate potential species-specific differences, we employed comparative in vitro test systems for brain development based on neurosphere cultures from human and mouse neural progenitor cells (hNPCs and mNPCs, respectively).
The hNPCs were seeded at a density of 2.5 x [10.sup.4]/well in laminin-coated 96-well plates.
Mitochondrial metabolic function of hNPCs was determined with the dye methylthiazoletetrazolium (MTT) to formazan [18].
The hNPCs were grown to 80% confluence in 3 cm laminin-coated culture dish and treated with MeHg (10 nM and 50 nM) for 24 h.
RESULTS: PBDEs do not disturb hNPC proliferation but decrease migration distance of hNPCs.
CONCLUSION: PBDEs disturb development of hNPCs in vitro via endocrine disruption of cellular TH signaling at concentrations that might be of relevance for human exposure.
HNPCs overexpressing ferritin, an iron storage protein, were found in the striatum of rat brains by MRI.