The transfusion of donor red blood cells (RBCs) that are incompatible with the recipient's blood type can lead to immune-mediated
hemolytic transfusion reaction, in which the recipient's immune system produces antibodies that destroy the donor cells.
Acute
Hemolytic Transfusion Reaction in a Patient with Bombay Phenotype: Implications for ABO Grouping.
Besides incompatible blood transfusion leading to the
hemolytic transfusion reaction, other transfusion reactions occurring in the recipients of blood transfusion are febrile reactions, allergic and anaphylactic reactions, circulatory overload, rarely immunologic complications, and transfusion-related acute lung injury (TRALI).
The clinical and laboratory findings did not support an acute
hemolytic transfusion reaction.
There was no history of recent transfusion, however, and the eluate was nonreactive--results that rendered a delayed
hemolytic transfusion reaction highly unlikely.
A mild acute
hemolytic transfusion reaction in a patient with alloanti-Ge3: a case report and review of the literature.
13) As dePEGylation ensues, donor RBC surface antigens would be exposed to host antibodies and
hemolytic transfusion reaction could occur.
Daniels (Bristol Institute for Transfusion Services) and Bromilow (DiaMed AG) describe the ABO, Rh, Kell, Duffy, Kidd, MNS, Diego, and Lewis blood group systems, and explain the clinical significance of blood group antibodies causing
hemolytic transfusion reaction and hemolytic disease of the fetus and newborn.
Acute
hemolytic transfusion reaction (AHTR) is of particular concern because it can cause severe complications and death (Payandeh et al.
22-26% of A2B individuals can have anti A1 antibodies that react a temperature below 25 degrees and cause
hemolytic transfusion reaction.
An antibody is considered clinically significant if antibodies of its specificity have been associated with hemolytic disease of the fetus and newborn, with a
hemolytic transfusion reaction, or with a decrease in red blood cell survival.
Delayed
hemolytic transfusion reaction with multiple alloantibody (anti S, N, K) and a monospecific autoanti-JKb in intermediate beta-thalassemia patient in Tabriz.
