Amplification of
hnRNP K Drives c-Myc-dependent malignancies and represent a novel therapeutic opportunity for hematologic malignancies.
Trotter, "Heterogeneous nuclear ribonucleoprotein (
hnRNP) F is a novel component of oligodendroglial RNA transport granules contributing to regulation of myelin basic protein (MBP) synthesis," The Journal of Biological Chemistry, vol.
hnRNP protein family members such as hRNPA2/B1 and hnRNP-C serve as m6A readers.
Biochemical studies showed an interaction with a wide range of RNA-binding proteins, including numerous
hnRNPs, splicing factors, and microprocessor complex (the Droshacontaining protein complex involved in microRNA processing) [26, 39, 40].
Timmerman, "The
hnRNP family: insights into their role in health and disease," Human Genetics, vol.
Heterogeneous nuclear ribonucleoprotein (
hnRNP) binding to hormone response elements: a cause of vitamin D resistance.
The influences of CEA on liver metastasis include survival of circulating tumor cells in blood vessels, activation of Kupffer cells by binding to
hnRNP M4, Kupffer cell membrane protein, altered liver microenvironments, and adhesion and survival of circulating CRC cells in the liver.
Foulkes, "
HnRNP Q has a suppressive role in the translation of mouse cryptochrome!," PLOS ONE, vol.
Allain, "The high kinetic stability of a G-quadruplex limits
hnRNP F qRRM3 binding to G-tract RNA," Nucleic Acids Research, vol.
Mechanistically, lincRNA-RoR has a 28-base heterogeneous nuclear ribonucleo-protein I- (
hnRNP I-) binding motif and directly interacts with phosphorylated
hnRNP I in the cytoplasm.
Nuclear matrix factor
hnRNP U/SAF-A exerts a global control of alternative splicing by regulating U2 snRNP maturation.