hnRNP

Acronym	Definition
hnRNP	Heterogeneous Nuclear Ribonucleoprotein Complex Protein

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Shortly after being injected, mice quickly developed large tumors, but when researchers used a biologic technique ("knockdown") to reduce hnRNP A2/B1 before injection, the mice developed only small tumors or no tumors at all.

These results suggest that hnRNP A2/B1 is a driving oncogene--a gene that causes normal cells to become cancerous--on its own and probably directly contributes to glioblastoma development," said Rotem Karni, Ph.

Karni said that "over expression and amplification of hnRNP A2/B1 correlate with poor prognosis of glioma patients, whereas deletion of the hnRNP A2/B1 gene correlates with better prognosis than average.

These biochemist researchers are continuously trying to identify the genes which are regulated by hnRNP A2/B1.

Israel discovers new therapy for brain cancer

TDP-43'un, hucre-ici kompartmanlar, hucre turleri ve hastalik evresine gore degisiklik gosteren buyuk hnRNP kompleksleri cercevesinde gorev yapmasi da olasidir.

TDP-43 proteinopathies: a new player in neurodegenerative diseases with defective protein folding/TDP-43 proteinopatileri: norodejeneratif konformasyon bozuklugu hastaliklarinda yeni bir oyuncu

hnRNP A1, an mRNA splicing regulator, exclusively stimulates maturation of miR-18a from the miR-17-92 cluster.

Recently, it was discovered that miR-328 has a second function, acting as a decoy by binding to hnRNP E2 and lifting its translational repression of an mRNA involved in myeloid cell differentiation [8].

miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts.

MicroRNAs and RNA-binding proteins

The effects of eurycomanone treatment on the expression levels of known lung cancer markers, heterogeneous nuclear ribonu-cleoprotein A2 and its splicing variant Bl (hnRNP A2/B1), were examined by immunoblotting using antibodies specific for hnRNP A2/B1.

Results from our study further showed that eurycomanone also targets other pathways affecting cell replication notably those involving p53 tumor suppressor gene, the lung cancer cell markers hnRNP A2/B1, annexin I and prohibitin.

Molecular characterization of the hnRNP A2/B1 proteins: tissue-specific expression and novel isoforms.

Eurycomanone suppresses expression of lung cancer cell tumor markers, prohibition, annexin 1 and endoplasmic reticulum protein 28