In the present study, we used a simple reaction time task to test the hypothesis that a single dose of indomethacin
would affect the information processing speed in healthy subjects.
Judicious use of brief courses of indomethacin
with careful monitoring of serum creatinine may be acceptable, but consideration of alternative treatment such as steroids is worthwhile in acute gout.
The contribution of nitric oxide (NO) and cyclooxygenase-derived products on the vascular response elicited by PA was examined by pretreatment of aortic rings with the NO synthase inhibitor L-NAME (100 [micro]M) and the cyclooxygenase-inhibitor indomethacin
(10 [micro]M) respectively, which were added to the organ bath 10 min before contracting the arterial rings (E+) with NE (0.
Astim, anemi, hepatik ve renal fonksiyon bozuklugu gibi durumlar indomethacin
kullanimina kontrendikasyon olustururlar (48,49).
Results of a Phase 3 study in patients presenting with an ongoing acute gout flare showed that compared to indomethacin
, a non-steroidal anti-inflammatory drug considered a standard of care, there was no significant benefit from combining indomethacin
with ARCALYST, as measured by the primary endpoint of the average intensity of gout pain from 24 to 72 hours after initiation of treatment.
One of the least selective NSAIDs, indomethacin
, seems to have the highest risk.
For example, about 3 percent of very low birth weight infants will develop spontaneous intestinal perforation, and the risk is approximately twofold greater if they have been treated with indomethacin
But if you put a prostaglandin blocker - like the drug indomethacin
- in the animals' water supply, you can reduce the rate of tumor metastasis.
Women with cervical lengths less than 3 cm and cervical funneling were instructed to take 25 mg of indomethacin
Pretreatment of endothelium-contained aortic rings with the non-selective inhibitor of cyclooxygenase, indomethacin
In most cases, however, he recommended switching them to a longer-acting NSAID such as naproxen sodium or indomethacin
for 5-7 days per week and then tapering it down to 3-4 days per week.
Bedford Laboratories will supply Indomethacin
for Injection USP as single dose vials containing indomethacin
sodium, equivalent to 1 mg indomethacin