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References in periodicals archive ?
Eukaryotic translation initiation factor 4E1 is the major transcript, contributing to ~95%-96% of the transcript total, followed by EIF4E3 with 2%-3% and EIF4E2 with less than 0.1%-2% (Fig.
Simvastatin inhibited oxidized low-density lipoprotein-induced apoptosis and reduced expression of protein kinase RNA-like endoplasmic reticulum kinase and phosphorylation of eukaryotic translation initiation factor 2a-subunit in human umbilical vein endothelial cells
A novel missense mutation in exon 5 of the eukaryotic translation initiation factor 2B subunit delta gene (EIF2B4), ENST00000493344: c.614C>T| p.Pro205Leu was detected (read depth: 60x).
Jopling et al., "Canonical initiation factor requirements of the Myc family of internal ribosome entry segments," Molecular and Cellular Biology, vol.
Upon activation, mTORC1 directly phosphorylates the eukaryotic translation initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) and S6 kinase 1 (S6K1) to promote protein synthesis [30].
Novoa et al., "Inhibition of a constitutive translation initiation factor 2[alpha] phosphatase, CReP, promotes survival of stressed cells," Journal of Cell Biology, vol.
The report provides comprehensive information on the Eukaryotic Translation Initiation Factor 4E (eIF-4E), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Abbreviations: ALL, acute lymphoblastic leukemia; ATF4, activating transcription factor-4; ATF6, activating transcription factor-6; CHOP, C/EBP homologous protein; CPT, cryptotanshinone; DDIT3, DNA damage-inducible transcript 3; elF, eukaryotic initiation factor; ER, endoplasmic reticulum; ERAD, ER-associated degradation pathway; IPA, Ingenuity Pathway Analysis; IRE1, inositol-requiring enzyme-1; mTOR, mammalian target of rapamycin; PERK, protein kinase RNA-like endoplasmic reticulum kinase; PI3K, phosphoinositide-3-kinase; ROS, reactive oxygen species; UPR, unfolded protein responses; XBPI, X-box protein 1.
Polyubiquitin, which is involved in light signal response, plant defense, and organogenesis (Dreher and Callis, 2007), and translation initiation factor, which directly regulates the synthesis of various proteins, were also detected in the expansion process of yacon tuberous root.
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with WolcottRallison syndrome.
Eukaryotic translation initiation factor 4B (eIF4B) is also phosphorylated by S6K1 and this phosphorylation promotes the recruitment of eIF4B to eukaryotic initiation factor 4A (eIF4A) at the translation initiation complex where it functions as a cofactor of eIF4A and increases its processivity [74].
Washington, August 21 ( ANI ): Researchers have discovered the way the protein, eukaryotic initiation factor 4E (eIF4E), acts upon cancer-promoting messenger RNA molecules.