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References in periodicals archive ?
Other methods use radiolabeled isotopes or nonradioactive contrast agents such as Cr51-EDTA, iohexol, and iothalamate; nonetheless, not only can these methods be difficult to perform but also they are invasive and not available in all laboratories or hospitals.
Other methods to measure GFR such as inulin and iothalamate clearance are more accurate albeit cumbersome and not practical to use in every day practice.
Evidence suggests that renal clearance can also be assessed using chromium 51-labeled EDTA ([sup.51]Cr-EDTA) or iothalamate infusion and plasma clearance of [sup.51]Cr-EDTA or iohexol.
Third, the definition of renal progression was based on changes in eGFR, rather than more precise measurements of renal function, such as proteinuria or iothalamate clearance.
The 99mTcdiethylenetriamine penta-acetic acid (DTPA) and iothalamate clearance correlate well with the results of inulin clearance and are being used in clinical practice5-7.
(11) A further LC-MS/MS method for quantifying iothalamate in plasma and urine can accurately assess glomerular filtration rate (GFR) in early stages of renal dysfunction to screen potential kidney donors.
As a consequence, some transplant centers have begun to use the non-radiolabeled iothalamate to determine GFR (Lujan et al., 2012).
The GFR was measured in 120 patients with chronic systolic heart failure (CHF) using [(125)I] iothalamate clearance (GFR(IOTH)) and estimated using the sMDRD and CKD-EPI equations.
[70] analyzed the effects of four different contrast media: ionic high-osmolar diatrizoate, ionic low-osmolar iothalamate, nonionic low-osmolar iohexol, and nonionic iso-osmolar iodixanol.
After adjusting for baseline iothalamate clearance and baseline proteinuria, each 1 mM increase in serum bicarbonate is associated with a 4% lower hazard of the clinical composite outcome of death, dialysis, or GFR event (hazard ratio 0.950, 95% confidence interval 0.916-0.985).