References in periodicals archive ?
MTT assay was performed to evaluate the effect of EIFAM, ESFAM, ORAC, 5FU, leucovorin, and a combination of 5FU and leucovorin (FULV) on the survival of COLO-205 cells (Figure 1).
With sufficient leucovorin rescue, none of the 11 patients experienced a potentially pathogenic complication and did not require invasive treatment, and all proceeded to the next cycle of chemotherapy.{Table 4}
Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer.
Aflibercept in combination with 5-fluorouracil, leucovorin and irinotecan (FOLFIRI) significantly improved survival in a phase III study of patients with mCRC who had a history of treatment with oxaliplatin (54), albeitthe outcome of aflibercept treatment in mCRC patients mainly depended on the history of previous treatment with bevacizumab.
A Randomized Controlled Trial of Fluorouracil Plus Leucovorin, Irinotecan, and Oxaliplatin Combinations in Patients with Previously Untreated Metastatic Colorectal Cancer.
Nine patients (6%) with stage 2 and 57 patients (60%) with stage 3 disease received adjuvant chemotherapy consisting of either a 5-fluorouracil analogue, or folfox/capox (regimens consisting of either 5-fluorouracil and leucovorin or capecitabine in combination with oxaliplatin).
He was started on dexamethasone to decrease the cerebral edema, levetiracetam for seizure prophylaxis, and empiric treatment with leucovorin, sulfadiazine, and pyrimethamine for possible toxoplasmosis.
(43) This is a frightening fact because sterile injectables are often critical life-saving drugs; they are the source of many oncology drugs such as Leucovorin and Doxil, as well as Naloxone, which is commonly used as a rescue drug, and Furosemide, a frequently used diuretic.
Leucovorin (LV) incorporated in 5FU based regimen enhances the cytotoxicity of 5FU.
Summary: Two simple and reproducible UV-Visible spectrophotometric methods were developed for the estimation of leucovorin in pure and injectable dosage forms.
In 2 Phase III trials, Capecitabine was at least as effective as 5-fluorouracil plus leucovorin and had a more favourable toxicity profile.