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References in periodicals archive ?
Modulation of leukotriene D4 attenuates the development of seizures in mice.
Metabolomic markers Malondialdehyde 4-Hydroxyhexenal 4-Hydroxynonenal Hexanal Heptanal Oktanal Nonanal Decanal Undodecanal 3-Nitrotyrosine 8-Hydroxy-2'-deoxyguanosine 5-Hydroxymethyluracil o-Tyrosine 3-Chlorotyro sine 8-Isoprostane Leukotriene B4 Proteomic markers Leukotriene D4 Interleukin 6 Interleukin 8 Monocyte chemotactic protein-1 Epidermal growth factor Soluble transferrin receptor LG3 fragment of endorepellin Tumstatin Endostatin BOX 2: Urinary markers that differentiated all groups of subjects: group 1 (healthy controls), group 2 (IgAN patients), and group 3 (disease controls).
An oral version of the drug marketed as a generic and by Astra Zeneca as Accolate', is a first-in-class anti- leukotriene and treatment for asthma.
Like zafirlukast, montelukast is a competitive antagonist for the cysteinyl leukotrienes. It binds with high affinity and selectivity to the CysLTl receptor subtype.
Leukotriene B5 is formed in human neutrophils after dietary supplementation with icosapentaenoic acid.
However, participants who reported a previous incidence of adverse reaction to montelukast or any other leukotriene inhibitor; history of hyper-eosinophilic disorder other than atopic disease; treatment with montelukast within four weeks from randomization; and asthma exacerbation or treatment with prednisone/other systemic steroid within four weeks from randomization were excluded from the trial.
Leukotriene receptor blocker montelukast protects against burninduced oxidative injury of the skin and remote organs.
To determine why this happened, the researchers first analyzed leukotriene levels.
Asthma medications comprise several drug classes, including leukotriene antagonists and steroid-based inhalers.
The 5-LO, with the aid of the accessory 5-LO-activating protein (FLAP), catalyzes the conversion of AA to 5-hydroperoxyeicosatetraenoic acid (5-HETE) and then to leukotriene A4 (LTA4) [3, 4], an unstable intermediate, which can be either metabolized by LTA4 hydrolase to LTB4, a potent chemoattractant, or conjugated to glutathione by LTC4 synthase (LTC4S) producing the cysteinyl LTs (CysLTs: LTC4, LTD4, and LTE4) [5].
Trials included those that evaluated the effects of fish oil (which contains EPA and DHA) or EPA alone on levels of prostaglandin E2, thromboxane B2, or leukotriene B4.
Montelukast, a specific leukotriene receptor antagonist (LTRA), provides clinical benefit to patients with chronic asthma with a once-daily, oral administration.