LMWCK

(redirected from low-molecular-weight cytokeratin)
AcronymDefinition
LMWCKlow-molecular-weight cytokeratin
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Antibodies to epithelial markers, such as cytokeratin (especially low-molecular-weight cytokeratin CAM 5.2) and EMA, typically stain RCC but not HAB.
Cytokeratin 20 (CK20), a low-molecular-weight cytokeratin, is specifically expressed in the superficial and in some of the intermediate cells of the normal urothelium.[5] Cytokeratin 20 is detected in some urothelial carcinomas and is associated with recurrence in the bladder.[6] Cytokeratin 7 (CK7) is another intermediate filament that is found in urothelial neoplasia of the urinary bladder.
However, most of the tumor cells, unlike SFT, are positive for high- and low-molecular-weight cytokeratin. The cells in the monophasic synovial sarcoma are spindle shaped.
The excised tumor tissue was fixed in 10% buffered formalin, processed for paraffin sectioning, and stained with hematoxylin-eosin and immunoperoxidase stains for glial fibrillary acidic protein, neurofilament protein, synaptophysin, low-molecular-weight cytokeratin, and desmin.
Sarcomatous mesothelioma typically is immunoreactive with low-molecular-weight cytokeratin, whereas most sarcomas either do not express cytokeratin or do so only focally.[18] Other soft tissue tumors, such as synovial sarcoma, fibrosarcoma, malignant fibrous histiocytoma, and malignant or benign peripheral nerve sheath tumors, can be excluded by their histologic appearance and immunophenotypes.
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