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LHRHALuteinizing Hormone-Releasing Hormone Analogue
LHRHALuteinizing Hormone-Releasing Hormone Agonist
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Failure to achieve castrate levels of testosterone during luteinizing hormone-releasing hormone agonist therapy: The case for monitoring serum testosterone and a treatment decision algorithm.
Time to normalization of serum testosterone after 3-month luteinizing hormone-releasing hormone agonist administered in the neoadjuvant setting: implications for dosing schedule and neoadjuvant study consideration.
Pai and colleagues report a small randomized controlled trial (RCT) examining whether men who receive 6 months of neoadjuvant androgen deprivation therapy for cytoreduction recover faster whether they receive a monthly luteinizing hormone-releasing hormone agonist (LHRHa) or an injection every 3 months.[sup.1] Unfortunately, due to accrual and eligibility issues, the authors were not able to complete the study in a timely manner and only 46 of the planned 100 patients were available for data analysis.
Prostate cancer patients, on the other hand, are often prescribed drugs known as luteinizing hormone-releasing hormone agonists (such as Lupron[R] or Zoladex[R]) that block testicular production of testosterone.
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