mAChRMuscarinic Acetylcholine Receptor
Copyright 1988-2018, All rights reserved.
References in periodicals archive ?
Muscarinic acetylcholine ([M.sub.1]-[M.sub.5]) receptors (mAChR ([M.sub.1]-[M.sub.5])) are found in high density in the cerebral cortex, striatum, diagonal band, hippocampus, amygdala, anterior and intralaminar nuclei of the thalamus, granule and purkinje cell layers of the cerebellum, and motor nuclei of the cranial nerves [91-93].
We have previously shown that the unilateral blockade of mAChR in the POA-AHA on dioestrous-1 or dioestrous-2 by implants of atropine slows follicular growth [13].
The sequences of primers were used in the polymerase chain reaction (PCR) using synthetic primers specific to choline acetyltransferase (ChAT), acetylcholine esterase (AChE), muscarinic acetylcholine receptors (Mj mAChR and [M.sub.2] mAChR), and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as follows:
26% occupancy of mAChR in human brain [26]; however no evidence about molar levels in cerebrospinal fluid was found and hence more investigation could be done this way.
monitored the degree of PLC[beta] activation by mAChR using the diacylglycerol-activated cation channel TRPC6 (transient receptor potential cation channel subfamily C member 6) as a biosensor for the PLC activity.
Within the central nervous system, acetylcholinergic neurotransmission is integrally involved in aspects of memory formation, affect, and motivational and multiple volitional behaviors, all of which are affected in schizophrenia."" Coordination of these cognitive and behavioral functions requires proper signaling through muscarinic receptors (mAChRs) and nicotinic receptors (nAChRs).
In order to find out if the activation of M1 mAChR was responsible for the neuroprotection observed, PC12 cells were pre-treated with atropine (a nonselective mAChR antagonist) or pirenzepine (a selective M1 mAChR antagonist) for 30 min respectively before 0.01 [micro]M lesatropane treatment.
Le minibus, qui venait de Tanger et devait se rendre a Marrakech, s'est renverse sur l'autoroute au niveau de la localite de Machr Ben Abou, suite a une crevaison, apprend-on aupres des autorites locales.
Other upstream factors are possibly involved in regulating the maturation of synaptic plasticity, including protein kinase C (PKC; MacDonald et al., 2001), hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels (Johnston and Narayanan, 2008), and metabotropic ligand-gated receptors (glutamate, mGluR; acetylcholine, mAChR: Abraham, 2008).
DAT/autorad (normal) 2008 D2R/autorad (normal) D1R/autorad (normal) CB1/autorad (normal) TH/immunohistochemistry (normal) DA-HVA/HPLC (normal) Abbreviations: autorad, autoradiography; CB1, cannabinoid receptor 1; ChAT, choline acetyltransferase; DA, dopamine; DAR, dopamine release; DOPAC, 3,4-dihydroxyphenylacetic acid; D2R, dopamine receptor; FDG, fluorodeoxyglucose; GABAaR, [gamma]-aminobutyric acid A receptor; GAD, glutamic acid decarboxylase; GP, globus pallidus; im, intramuscular; iv, intravenous; mAChR, muscarinic acetylcholine receptor; MRS, magnetic resonance spectroscopy; ND, not determined; IME, norepinephrine; sc, subcutaneous; SN, substantia nigra; SNpr, substantia nigra pars reticulata; TH, tyrosine hydroxylase.
The effects of 60 [micro]g/ml of TDE were completely blocked by 10 [micro]M atropine, an mAChR antagonist (Fig.
Decrements in the striatal dopamine system may be reflected as motor behavioral deficits, while the central cholinergic systems play a major role in the processing of memory through the activation of muscarinic receptors (mAChR).