mAChRMuscarinic Acetylcholine Receptor
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monitored the degree of PLC[beta] activation by mAChR using the diacylglycerol-activated cation channel TRPC6 (transient receptor potential cation channel subfamily C member 6) as a biosensor for the PLC activity.
Therefore, altered ACh neurotransmission may contribute to the cognitive and behavioral symptoms of schizophrenia because the ACh system is also widespread throughout the cortex and acts at multiple mAChRs and nAChRs.
Neuroprotective effects of lesatropane are mediated through Mi mAChR inPC12 cells
In order to find out if the activation of M1 mAChR was responsible for the neuroprotection observed, PC12 cells were pre-treated with atropine (a nonselective mAChR antagonist) or pirenzepine (a selective M1 mAChR antagonist) for 30 min respectively before 0.
This possibility is supported by our findings where the transient depression resulting from TDE application was prevented by mAChRs blockade.
We studied the influence of different concentrations of various detergents and temperatures on the fluidity of membranes, and compared these data with the ability of the detergents to solubilize mAChR.
The Sf9 cells expressing different mAChR subtypes were grown as described in [5] by Dr.
Four senior military officers each from president Salva Kiir's government and the armed opposition faction led by former vice president, Riek Machr, would lead the workshop to discuss demilitarization of the capital, Juba, and determine the size and composition of forces to be deployed in the national capital as well as in other state capitals, among others.
In support of this interpretation, higher doses of parathion administered to pregnant rats throughout gestation do affect ChAT but only when the dose is sufficiently high to elicit clear signs of maternal toxicity and down-regulation of mAChR binding (Gupta et al.
Riek Machr receives LRA top negotiator and his delegations to Juba Peace talks, Juba Feb 18, 2008 (ST)
There were several studies that examined both motor activity and mAChR expression after developmental exposure to pyrethroids.
c), a blocker of mAChRs, failed to modify the capsaicin-induced nociceptive responses in a significant manner.