In the proposed MCTR biosynthetic pathway, human macrophage 12-LOX is the initiating enzyme, converting docosahexaenoic acid to 13S,14S-epoxide intermediates, which is converted to MCTR1 by leukotriene C4 synthase (LTC4S) and catalyzed glutathione S-transferase MU 4 (GSTM4).
Recently it was reported that macrophages produce a family of bioactive peptide-conjugated mediators known as maresin conjugates in tissue regeneration (MCTR) .
Abbreviations SPMs: Specialized proresolving lipid mediators DHA: Docosahexaenoic acid PMNs: Polymorphonuclear leukocytes Ri: Resolution interval EPA: Eicosapntemacnioc acid MCTR: Maresin conjugate in tissue regeneration sEH: Soluble epoxide hydrolase 12-LOX: 12-Lipoxygenase LTC4S: Leukotriene C4 synthase GSTM4: Glutathione S-transferase MU 4 GGT: Gamma-glutamyltransferase DPEP: Dipeptidase NF-[kappa]B : Nuclear factor kappa B PDGF: Platelet-derived growth factor TGF-[beta]1: Transforming growth factor [beta]1 TRPV1: Transient receptor potential V1.
The rectal temperature tended to remain higher in the MCTR group compared to the other groups until it reached a significantly higher value compared to all the other groups at 114 h (approx.
uberis (i.e., MTZD and MCTR) compared to the groups receiving intramammary infusion of saline at the beginning of the trial, but the differences disappeared just before IMI.
For more advanced zonular instability the mCTR
or CTS both of which can be sutured to the sclera for improved fixation may be considered.
MCTR and MCTO thresholds and objectives could be specified in the capability needs documentation, such as the Initial Capabilities Document, Capability Development Document, and Capability Production Document.
Data to support MCTR and MCTO targets could be obtained as part of the Joint Capabilities Integration & Development System (JCIDS) process.
Category I of the MCTR
Guidelines regarding what is controlled includes "complete rocket systems (including ballistic missile systems, space launch vehicles, and sounding rockets) and unmanned air vehicle systems (including cruise missile systems, target drones, and reconnaissance drones) capable of delivering at least a 500 kg payload to a range of at least 300 km as well as the specially designed 'production facilities' for these systems." A look over the UAV marketplace (see "A Sampling of Unmanned Aerial Vehicles." JED, March 2001, p.
Turning to General Atomics, precisely, and like the RQ-4 series, the MQ-9 (earlier Predator-B) is covered by MCTR
(Missile Technology Control Regime) guidelines, and is therefore made available to very few nations.
South Korea will join the global Missile Technology Control Regime (MCTR