mGFRMeasured Glomerular Filtration Rate
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The researchers found that in all participants, there were close linear correlations for VFI-based mGFR values with the iohexol-based mGFR values.
"The VFI-based approach allows for the rapid determination of mGFR at the bedside while maintaining patient safety and measurement accuracy and reproducibility," the authors write.
Therefore, we systematically reviewed published studies comparing mGFR with eGFR, calculated from both MDRD and CKD-EPI equations in populations relevant to a primary care setting.
The primary endpoint, change in mGFR from baseline to year 3, was compared between treatment groups using an analysis of covariance (ANCOVA) with the randomized group as a factor and the baseline value as a covariate.
In 1976 the original Cockcroft-Gault (CG) equation estimated the creatinine clearance (not mGFR using a gold standard method).6 The study population only included white male patients and a factor was used to estimate the CrCl for females (it was assumed that female lean body mass was approx 15% lower).6 The equation was derived using an unstandardised creatinine assay.
However, both equations overestimated mGFR. Applying modification factors for slope and intercept to the CKD-EPI equation to create a CKD-EPI Pakistan equation (such that eGFR [CKD-EPI (PK)] = 0.686 x eGFR [CKD-EPI] to the power 1.059) eliminated bias and improved accuracy (P30, 81.6% [95% CI, 78.4%-84.8%]; P 40 years in 12 representative communities in Karachi, Pakistan.
pooled data on mGFR and cystatin C concentrations in 4960 individuals from 3 groups [3495 Swedish adults, 763 Japanese adults, and 702 Swedish and Dutch children, referred to as CAPA (Caucasian and Asian pediatric and adult subjects)].
We assessed the performance of the 4-v MDRD equation, both with and without the ethnicity factor, and the Cockcroft-Gault equation normalized to 1.73 [m.sup.2] relative to that of mGFR by use of Spearman correlation coefficient, weighted Deming regression analysis, median percentage difference between estimated and measured GFR (percentage bias), and proportion of eGFR within 30% of mGFR ([P.sub.30=).