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References in periodicals archive ?
Rearrangement of Gell and Coombs classification and subgroups of type 4 reactions (6) Type Mechanism Example Type 4a TH1 lymphocytes activate Tuberculin monocytes/macrophages by reaction releasing interferon-[gamma] Type 4b TH2 lymphocytes release IL-4, MPE (with IL-5 and IL-13 and activate eosinophilia) eosinophils Type 4c Cytotoxic T cells (CD4+ and Maculopapular and CD8+) migrate to the tissue bulleous eruptions and lead to cell death Type 4d T-cell-mediated neutrophilic Acute diffuse inflammatory response exanthematous pustulosis MPE: maculopapular eruption Table 5.
(2) The most common presentation is a maculopapular eruption involving the face.
Only 8 individuals (5.71%) with cutaneous presentations were found among the population, of whom there were 2 cases (25%) of maculopapular eruptions, 2 cases (25%) of erythema nodosum-like lesions, 1 case (12.5%) of psoriasiform lesions, 1 case (12.5%) of palmar erythema, 1 case (12.5%) of malar eruption, and 1 case (12.5%) of palmar eczema.
Typical cutaneous adverse drug reactions (cADRs), such as maculopapular eruptions (MPEs), often show varying degrees of vacuolar interface dermatitis associated with nonspecific eosinophilic and/or neutrophilic infiltrates [1].
The second period during which epidermal separation occurs and vesciles and bullae are formed follows the early stage of the disease which is characterized by red-purple maculopapular eruptions (1).
Maculopapular eruptions, erythematous eruptions, edema, and periorbital edema are the most common adverse events seen 121.
Although the lymphocyte transformation test (LTT) is a reliable method to identify the incriminating drug in many types of drug eruptions such as maculopapular eruptions, acute generalized exanthematous pustulosis, and drug induced hypersensitivity syndrome, positive LTT reactions are rarely obtained in patients with FDE.
The study found that the majority of these drug reactions were related to antibiotics and that morbilliform and maculopapular eruptions were the most common pattern observed.