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References in periodicals archive ?
The prevalence of megaloblastic anemia varies from 74% to 13% in similar studies [Table 2], whereas it is only 4.3% in the present study and this could probably be an underestimation due to lack of investigations or reporting.
In summary, we report an 18-year-old male patient who presented with myelopathy without megaloblastic anemia with highly increased MMA, tHcy, and slightly reduced concentrations of vitamin [B.sub.12] from vitamin [B.sub.12] deficiency caused by [N.sub.2]O abuse.
In megaloblastic anemia, patients has low RBCs count and RBC are larger in size ( >100fl).
Hungry bone syndrome is a severe complication of neglected primary hyperparathyroidism, which associated with iron-deficiency, megaloblastic anemia and bone fibrosis, besides the renal failure, suggests that the severity was determined by the term of hyperparathyroidism and the increased number of complications.
Diphyllobothrium pacificum infection is seldom associated with megaloblastic anemia. Am J Trop Med Hyg.
In a study by Gayathri et al., (3) Megaloblastic anemia was the commonest cause of pancytopenia (70.04%) and aplastic anemia was the second common cause (17.26%).
Patients with a history of other inflammatory or noninflammatory arthritis, megaloblastic anemia, malignancies, renal disease with severe renal insufficiency, chronic infectious and inflammatory diseases, and other diseases in the stage of decompensation were excluded from the study.
In fact, vitamin B12 deficiency is serious business, which can result in megaloblastic anemia (a blood disorder with larger than normal red blood cells) and symptoms that may include numbness and tingling in the arms, difficulty walking, memory loss, and disorientation.
Indeed, a long line of clinical observations in the past has noted that states of anemia associated with increased endogenous erythropoietin (EPO) levels (e.g., chronic inflammation and iron deficiency) also have chronic elevation of platelets counts, unless there is a coincidental DNA synthesis impairment (megaloblastic anemia).
It has been found that in Pakistan 1.3% are anemic and among them 11.4% are suffering from pernicious anemia, a variant of megaloblastic anemia which , is caused by deficiency or defective absorption of vitamin B12 in adults and folate deficiency in children resulting into oral ulceration, mucosal bleeding and glossitis12,13.
High-dose oral B12 ([greater than or equal to] 1000 mcg/d) can cure cobalamin deficiency, and may also induce and maintain remission in patients with megaloblastic anemia. (1)