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Saffron significantly improved mean BCVA 0.69 letters (p = 0.001) and reduced mean-pooled mfERG latency by 0.17 ms (p = 0.04) compared to placebo.
MfERG ring analysis was selected to differentiate changes of the bioelectrical responses of the central foveal regions with respect to the more eccentric retinal areas in the macular region.
PCD is a very rare retinal disease originally characterized by normal fundoscopic appearance, normal fluorescein angiographic imaging, mildly reduced photopic potentials with preserved scotopic potentials on ffERG, and relative preservation of foveal cone function by mfERG. The name "peripheral cone dystrophy" is unfortunately a misnomer, as central rather than peripheral cone involvement is a prominent feature, but the name was selected to contrast "central" cone dystrophy, or OCMD, because the foveola is preserved.
The mfERG is used to assess the cone function of the posterior pole.4 The stimulus is a collection of either 61 or 103 hexagons over a field diameter of 40-50[degrees] (see Figure 8).
2) Identify characteristic functional retinal findings of ICSC by appropriate electrophysiological test (mfERG).
Kyhn et al., "Functional recovery after experimental RPE debridement, mfERG studies in a porcine model," Graefe's Archive for Clinical and Experimental Ophthalmology, vol.
However, clinical trials to determine not only the effectiveness and safety but also the compliance of a noninvasive route to administer these drugs, as well as a standardization of the methods for monitoring neurodegeneration such as mfERG and frequency domain-OCT, are needed.
(15) There are also studies demonstrating retinal dysfunction using focal and mfERG, despite normal ERG findings.
* Mean BCVA improved 0.73 letters (p=0.006) and mean pooled mfERG response density improved 2.8% (p=0.038).
Furthermore, multifocal ERG (mfERG) showed a decrease of amplitudes bilateral.
In this study, multifocal electroretinogram (mfERG), which allows detailed topographical mapping of the retinal function in the central macula, was documented and compared before and after surgery in patients with large MHs (>400 [micro]m) who underwent inverted ILM flap technique assisted PPV, trying to combine the mfERG results to the microstructural changes detected by spectral-domain optical coherence tomography (SD-OCT).
(1) Fundus fluorescein angiogram (FFA) and full-field electroretinogram (ERG) are normal, whereas results of multifocal ERG (mfERG) of the central retina are markedly reduced.
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