Nonspecific interstitial pneumonia
(NSIP) pattern predominates in most CTD-ILD whereas usual interstitial pneumonia (UIP) pattern is more common in RA.
Janssen et al., "Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia
," Chest, vol.
APTT: Activated partial thromboplastin time BMI: Body mass index CVD-ILD: Collagen vascular disease-associated interstitial lung disease D-ILD: Drug-induced interstitial lung disease DLCO: Diffusion capacity for carbon monoxide DPLD: Diffuse parenchymal lung disease FVC: Forced vital capacity HP: Hypersensitivity pneumonitis HRCT: High resolution computed tomography ICU: Intensive care unit INR: Prothrombin time international normalized ratio IPF: Idiopathic pulmonary fibrosis MDD: Multidisciplinary discussion mPAP: Mean pulmonary artery pressure NSIP: Nonspecific interstitial pneumonia
SLB: Surgical lung biopsy TBLC: Transbronchial lung cryobiopsy UIP: Usual interstitial pneumonia VATS: Video-assisted thoracoscopic surgery.
Systemic sclerosis-ILD is typically a nonspecific interstitial pneumonia
(NSIP) pattern with groundglass opacities, interstitial pulmonary fibrosis, and honeycomb cystic changes in the lower lung zones [5, 6, 23].
AUC: Area under the curve BALF: Bronchoalveolar lavage fluid BP: Bacterial pneumonia CCL18: CC-chemokine ligand 18 [D.sub.LCO]: Diffusing capacity of the lung for carbon monoxide ECLIA: Electrochemiluminescence immunoassay ELISA: Enzyme-linked immunosorbent assay [FEV.sub.1]: Forced expiratory volume in 1 second HC: Healthy controls HP: Hypersensitivity pneumonia HR: Hazard ratio HRCT: High-resolution computed tomography ILDs: Interstitial lung diseases IPF: Idiopathic pulmonary fibrosis KL-6: Krebs von den Lungen-6 MMP-7: Matrix metalloproteinase-7 NSIP: Nonspecific interstitial pneumonia
ROC: Receiver operating characteristic SP-A: Surfactant protein-A SP-D: Surfactant protein-D VC: Vital capacity.
One of the high-resolution computarized tomography (HRCT) sections of a patient with nonspecific interstitial pneumonia
(NSIP) is shown in Picture 2.
The major IIPs include idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia
(NSIP), acute interstitial pneumonia (AIP), and bronchiolitis obliterans organizing pneumonia (BOOP).
Dr B Schar from Wits provides a cogent overview of idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia
, the two common idiopathic interstitial pneumonias.
High resolution computed tomography features of nonspecific interstitial pneumonia
and usual interstitial pneumonia.
On imaging, common forms of toxic changes are fibrosing alveolitis (with a pattern often resembling findings in nonspecific interstitial pneumonia
), predominantly subpleural consolidations (resembling cryptogenic organizing pneumonia or eosinophilic pneumonia), and in the more acute setting hypersensitivity reactions with imaging findings ranging from ground glass opacities and alveolar consolidations to severe diffuse alveolar damage indistinguishable from ARDS [38,40] (Figure 7).
Cyclophosphamide and low-dose prednisolone in idiopathic pulmonary fibrosis and fibrosing nonspecific interstitial pneumonia
. Eur Respir J.
On biopsy, a number of pathological patterns may be seen, including usual interstitial pneu-moxiitis, nonspecific interstitial pneumonia
, and RB-ILD, Dr.