The osteoclast-like giant cells contained multiple relatively monomorphic and bland-looking nuclei (ranging from 3 to 25 per cell) with abundant cytoplasm.
One tumor appeared to be an invasive malignant neoplasm that exhibited the typical features of a salivary duct carcinoma; the other appeared to be an osteoclast-like giant-cell tumor.
The giant-cell tumor, which accounted for 60 to 70% of the tumor mass, contained two components--one multinuclear and osteoclast-like and the other mononuclear:
A number of multinuclear, osteoclast-like giant cells were rather regularly distributed throughout the tumor.
6] Classic microscopic features include proliferating spindle cells and osteoclast-like giant cells lining pseudovascular cavernous spaces; a fibromyxoid background substance with scattered chondroid and osteoid changes often may be recognized.
Giant cell tumor has multinucleated osteoclast-like giant cells, often displaying innumerable nuclei ([is greater than] 20 up to 100), and usually does not have the characteristic fibromyxoid milieu with chondroid or osteoid changes.
Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures.
The effect of hemopoietic growth factors on the generation of osteoclast-like cells in mouse bone marrow cultures.
3] in osteoclast-like multinucleated cells formed from mouse bone marrow cells.
1a] clearly identified LCH histiocytes in proximity to the osteoclast-like giant cells.
4,10,11] The presence of variable numbers of multinucleated osteoclast-like giant cells, as a morphologic concomitant in these LCH lesions, supports such a pathogenic sequence.
Furthermore, the immunoreactivity for ACE antigen on non-Langerhans cell histiocytes, occasional osteoclast-like giant cells, and endothelial cells in this series of cases accords with earlier reports that collectively document its presence on monocytes, macrophages, and endothelial cells.