Microscopical examination showed sheets of round to oval mononuclear cells with bland chromatin and conspicuous nucleoli uniformly interspersed with numerous osteoclast-like
giant cells with nuclei similar to that of the mononuclear cells confirming the histopathological diagnosis of giant cell tumor [Figure 3].
11] Histologically, PGCG is described as a non-encapsulated mass of tissue, containing numerous multinucleated osteoclast-like
giant cells lying in a very cellular and vascular stroma.
3) However, cases that may be morphologically similar to CCSLGT have been reported previously, including by Alpers and Beckstead, (4) who reported a "malignant neuroendocrine tumor of the jejunum with osteoclast-like
tumor giant cells" in 1985.
The primary goal of the research is to demineralize calcified vascular calcification using osteoclast-like
cells differentiated from monocytes.
Using unbiased global proteomics (study of proteins), the researchers were able to examine osteoclast-like
cells in the vasculature to determine which proteins induced osteoclast formation.
As shown in Figure 1A and B, RANKL induced the formation of TRAP-positive multinuclear giant osteoclast-like
cells and BIX01294 significantly reduced the number of osteoclast-like
cells in a dose-dependent manner.
Giant cell tumors of bone consist of stromal cells expressing RANKL and osteoclast-like
giant cells expressing RANK receptor.
2006) and OPG are critical in the regulation of the formation of osteoclast-like
From a morphologic point of view, several secondary changes have been described as being associated with AFX, such as keloidal areas, myxoid or chondroid changes, osteoclast-like
giant cells, sclerosis, fibrosis, pigmentation, hyalinization, or hemorrhagic areas (1-3).
Effects of high calcium concentration on the functions and interactions of osteoblastic cells and monocytes and on the formation of osteoclast-like
The Papanicolaou smear was nondiagnostic, but the Wright-Giemsa stain was richly cellular and populated by three components: (1) numerous osteoclast-like
multinuclear giant cells, (2) multiple malignant-appearing mononuclear and multinuclear cells, and (3) broad, tightly cohesive, flat sheets of large polygonal epithelial cells (figure 1):
Effects of lead on osteoclast-like
cell formation in mouse bone marrow cell cultures.