Also found in: Dictionary, Medical, Encyclopedia, Wikipedia.
p53Tumor Suppressor Gene
References in periodicals archive ?
The P53 pathway seems to play a critical role in therapeutic response both as a diagnostic and marker in the prognosis of therapeutic treatment effects.
In the new study, the researchers used a genetic technique to make zebra-fish turn green when the p53 gene was switched on to explore the way the gene was regulated.
Now, researchers from the University of Tokyo and colleagues report in the July 23 Nature that p53 helps slice RNA into small regulatory molecules called microRNAs.
Demonstrating how p53 utilizes microRNAs to stop the growth of tumor cells through facilitating apoptosis, sheds much light on this critical cancer fighting pathway," said Prof.
This research also shows that abnormal p53 function is a common and fundamental molecular defect that is a predictive marker for ADVEXIN efficacy, which is consistent with ADVEXIN's mechanism of action -- restoration of p53 function -- and is an example of targeted molecular therapy.
DNA damage results in p53 activation, mdm2 down-regulation and consequently three cellular responses are bound to follow namely, growth arrest at [G.
The p53 gene is mutated in about half of all types of cancer, and cancers with the p53 mutation tend to be clinically aggressive and difficult to cure, said Mingxie Che, M.
In addition some patents address adenoviral p53 compositions, production, purification and use in the treatment of cancer.
Direct sequencing is commonly used for detecting p53 alterations (24), but this method is time-consuming and costly; therefore, other methods of screening for p53 changes have been developed, such as immunohistochemistry and SSCP analysis.
As expected, mutant mice with excess p53 developed far fewer cancer tumours than normal animals - but they did not live longer.
P53 curbs the spread of cells that have damaged DNA.