Desflurane post-conditioning protects the human myocardium through the RISK activation of P70S6K and eNOS, and leads to GSK3[beta]-mediated closure of the mPTP (99).
Role of Erk1/2, p70s6K, and eNOS in isoflurane-induced cardioprotection during early reperfusion in vivo.
On the other hand, activation of the Akt/mTOR/p70S6K
pathway gradually increased after more than 1 week, and the activation of these proteins, especially p70S6K
, correlated with the amount of muscle hypertrophy (Bodine et al.
is involved in protein synthesis, cell growth and apoptosis, embryonic development, and cancer (Fenton and Gout, 2011; Brian et al.
Phosphorylation of p70S6k
correlates with increased skeletal muscle mass following resistance exercise.
Coagulin-L decreased phosphorylation of mTOR and its associated proteins P70S6K
and 4EBP during adipogenesis (Fig.
3] significantly and dose-dependently decreased phosphorylation of Akt and p70s6k
proteins during myogenic differentiation.
In fact, tuberin can negatively regulate the activity of protein S6 and p70S6K
, specifically, and disruption of this mechanism can explain the abnormal cell growth in PEComas.
, a serine-threonine kinase that controls cell growth and is at the end of a pathway that is frequently activated through mutation or gene amplification in many human tumors.
Rapamycin inhibits constitutive p70s6k
phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells.
1,17-32) Additionally, the activation of PKC-[alpha] in the form of plasmalemmal translocation in some of the tumor cells and the coexpression of plasmalemmal phospholipase D1 provides another independent pathway for the activation of p70S6K
signalling appears to play a regulatory role in this system via 4EBP1.