pFAKPhosphorylated Focal Adhesion Kinase
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8 showed that EEAC significantly dose-dependently affect pFAK, p-JNK1/2, and p-p38 proteins at concentrations from 0.125 to 1.0 [micro]g/ml.
showed that the expression of pFAK (phosphorylated-focal adhesion kinase), HIF-L[alpha] (hypoxia-inducible factor-1a), vascular endothelial growth factor (VEGF) and VEGF2 in CTCs of patients with metastatic breast cancer could explain the metastatic potential of these cells and may provide a therapeutic target for their elimination (55).
Markers expressed in Type of breast cancer CTCs HER2 Operable: after adjuvant chemotherapy hMAM (a) Operable CK-19, hMAM, (a) HER2 Early CK-19, HER2, MAGE-A3, Early hMAM, TWIST-1 CK-19 Early: after adjuvant chemotherapy ER/PR Early HER2 Early CK-19, HER2 Patients prior to chemotherapy HER2 Neoadjuvant HER2 Metastatic HER2 Metastatic EpCAM, MUC1, HER2, Metastatic ER, PR VEGF, VEGF-2, HIF-1[alpha], Metastatic pFAK Markers expressed in No.