pVHLVon Hippel Lindau Protein
References in periodicals archive ?
Ohh, "pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development," Molecular and Cellular Biology, vol.
pVHL.--pVHL is normally expressed in benign pancreaticobiliary epithelial cells.
RACK1 causes polyubiquitination of HIF-1[alpha] by binding to Elongin C and ultimately producing Ubi-HIF-1[alpha], which is degraded by proteasomes [92]; RACK1-induced degradation of HIF1a is independent of oxygen, pVHL, and PHD.
LANA, KSHV latency-associated nuclear antigen [24], increases the degradation of pVHL whereas the PHDs 1 and 3 are degraded by proteasomes upon EBV infection [25].
VHL gene was mapped to the short arm chromosome 3 (3p25), it comprises 3 exons that encode for the 2 isoforms of the pVHL protein [56].
The normal function of the VHL gene product (pVHL) is destroying hypoxia-inducible factors (HIFa) inside cells.
It is well-established that VHL (pVHL) regulates the protein stability of the transcription factor Hypoxia-Inducible Factor (HIF)-1 alpha through proteolysis.
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature 417:975-978.
Additional immunomarkers also revealed the tumor cells to be reactive to [alpha]-methylacylCoA racemase (P504S), patchy for von Hippel-Lindau tumor suppressor (pVHL), and focally weak for carbonic anhydrase IX (CAIX).
Therefore, pVHL cannot interact with HIF-1[alpha], and finally the monomer remains in the cytoplasm and migrates to the nucleus, binding to constantly expressed [beta]-monomer and forming the HIF-1[alpha] transcription factor [16].
En normoxia tisular, la HIF-[alfa] sufre hidroxilacion por la PHD-2 y por la FIT-1; luego, la proteina de von Hippel-Lindau (pVHL) reconoce a este complejo hidroxilado y lo marca para su degradacion por el proteosoma.