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Related to paroxysmal nocturnal hemoglobinuria: Paroxysmal cold hemoglobinuria
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B) Bactericidal activity of pool tested in panel A measured against the nongroupable (NG) case isolate from a 16-year-old girl with paroxysmal nocturnal hemoglobinuria who died of meningococcal disease after treatment with eculizumab (data from 5 replicate assays).
Kawagoe et al., "Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria," Cell, vol.
Hillmen, "Thrombosis in paroxysmal nocturnal hemoglobinuria.," Blood, vol.
FDA report: eculizumab (Soliris) for the treatment of patients with paroxysmal nocturnal hemoglobinuria. Oncologist 2008; 13:9931000.
Paroxysmal Nocturnal Hemoglobinuria cell in Patients with bone marrow failure syndrome.
This report provides comprehensive information on the therapeutic development for Paroxysmal Nocturnal Hemoglobinuria, complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
Paroxysmal nocturnal hemoglobinuria from bench to bedside.
Paroxysmal nocturnal hemoglobinuria is a rare, chronic stem-cell disease in which complement-mediated intravascular hemolysis causes anemia, fatigue, and venous thromboembolism.
Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry.
Siddappa and colleagues presented a rare case of renal hemosiderosis appearing with renal failure due to repeated blood transfusion (about 2 per month) over past 2 years for chronic refractory anemia.[sup.25] Three cases of paroxysmal nocturnal hemoglobinuria with renal hemosiderosis and renal failure were reported by Nair and colleagues.[sup.10] Most patients with renal hemosiderosis also have renal failure.
Austen, "Deficiency of the complement regulatory protein, "decay-accelerating factor", on membranes of granulocytes, monocytes, and platelets in paroxysmal nocturnal hemoglobinuria," The New England Journal of Medicine, vol.
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