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Some reports suggest that the RNA could be original pgRNA but it is not known whether these HBV RNA virions are infectious.
(rc-DNA = relaxed circular DNA; HBV = hepatitis B virus; cccDNA = covalently closed circular DNA; pgRNA = pre-genomic RNA.)
(HBV = hepatitis B virus; rcDNA = relaxed circular DNA; cccDNA = covalently closed DNA; pgRNA = pre-genomic RNA; HBsAg = hepatitis B surface antigen.)
(HBV = hepatitis B virus; rcDNA = relaxed circular DNA; HBsAg = hepatitis B surface antigen; cccDNA = covalently closed circular DNA; pgRNA = pre-genomic RNA.)
(HBV = hepatitis B virus; rcDNA = relaxed circular DNA; cccDNA = covalently closed circular DNA; pgRNA = pre-genomic RNA; HBsAg = hepatitis B surface antigen.)
C, Expression levels of HBV pgRNA and capsid-associated virus DNA in hepatoma cells after co-transfection with pHBV1.3 and miR-30c mimic, inhibitor or scramble control for 72 h.
There was a slight tendency of pgRNA expression reduction in cell cultures of transfected cells with HBV genotypes C and H and the treatment of 30 [micro]g/mL of M oleifera (Figure 1(b)).
The pgRNA expression decreased with an increase of M.
oleifera treatment decreased mRNA-IFN[beta], the decrease in cellular pgRNA and in the HBV-DNA observed in the supernatant from Huh7-transfected cells with genotype C could be influenced by a different mechanism not by IFN[beta] production.
oleifera had no cytotoxic effect on Huh7 cells at selected concentrations (30, 45, and 60 [micro]g/mL) but modulated the pgRNA levels and HBsAg secretion positively in Huh7 cells transfected with genotypes C and H of HBV.
(b) pgRNA expression of Huh7 cells transfected with genotype C (white bars) or H (black bars) of HBV and treated with Moringa oleifera.
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