Hicks JK, Bishop JR, Sangkuhl K, et al; Clinical Pharmacogenetics
testing data to select the appropriate drug and dosage for the patient can have considerable benefits for all stakeholders.
2010 Jan;26 Suppl 10:S16-20), which found that pharmacogenetic
testing can help identify patients who are more likely to respond to opioid treatment, exactly which opioids would produce the most favorable responses, which patients would be at higher risks for opioid-related adverse events and drug interactions, and which patients would require higher-than-average opioid doses.
Study authors also acknowledged that their pharmacogenetic
algorithms showed significant differences of predictability across different ethnic groups and that these algorithms performed better at predicting the optimal maintenance doses for nonblack patients than they did at predicting such doses for black patients.
Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.
Moreover it is already successfully applied at the bedside as a powerful pharmacogenetic
Professor Munir Pirmohamed, who is leading the pioneering programme, said: "The study of pharmacogenetics
is vital to the public health of this country
Professor Pirmohamed said: "The study of pharmacogenetics
is vital to the public health of this country.
These genetic differences have spawned the fields of pharmacogenomics and pharmacogenetics
It has also released comments received on draft reflection paper on the use of pharmacogenetics
in the pharmacokinetic evaluation of medicinal products http://www.
Testing for neuro-psychiatric disorders are expected to eventually dominate pharmacogenetics
, increasing from 50,000 in 2006, to 9 million in 2013.
The study of how genetic factors influence a person's response to a drug is called pharmacogenetics