Pei et al., "Comparison of single daily dose of methimazole and propylthiouracil
in the treatment of Graves' hyperthyroidism," Clinical Endocrinology, vol.
Pires de Carvalho, "Thyroid [Ca.sup.2+]/NADPH-dependent H2O2 generation is partially inhibited by propylthiouracil
and methimazole," European Journal of Biochemistry, vol.
Considering that a series of malformations occur with use of methimazole in pregnancy, propylthiouracil
should be preferred in the first trimester (19).
Our patient's medications were changed to propylthiouracil
150 mg every 8 hours and propranolol 10 mg twice a day until a euthyroid state was achieved and she could tolerate a general anesthetic with out precipitating a thyroid storm.
The complementary list includes Lugol's iodine, potassium iodide, and propylthiouracil
Carbimazole and propylthiouracil
are examples of commonly used anti-thyroid drugs that are effective in reducing the production of thyroid hormones.
Newborn rats were assigned to groups of 6 rats each for subcutaneous (sc) injection of 0.5, 1.0, 1.5, 2.0, 4.0, or 50.0 [micro]g/100 g body weight (BW) triiodothyronine ([T.sub.3]; Sigma, USA; Hyper-5 group), groups of 12 rats each for sc injection of 5 or 10 mg/100 g BW propylthiouracil
(PTU; Sigma; Hypo-5 group), or saline (0.9% NaCl; Control-5 group), for 5 days beginning on P1.
Therapeutically, D1 is inhibited by propylthiouracil
, which is used to treat hyperthyroidism.
Hyperthyroidism is a common endocrine disorder and is mainly treated with anti-thyroid medications like propylthiouracil
(PTU) and carbimazole.
Supertasters are defined by whether they can detect the presence of two bitter-tasting compounds, phenylthiocarbamide (PTC) and propylthiouracil
(PROP), and geneticists have shown that this ability depends to a large extent on certain variations of a gene known as TAS2R38.
His liver functions improved and after 10 days, we started propylthiouracil
. He has been on it for three months and his liver function tests were normal.
Results of some derivatives of 2-thiouracil, such as propylthiouracil
, which was used as antithyroid drug, produced thyroid cancers in human and in some animals such as mice, rats, and hamsters .