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Prostacyclin and prostacyclin analogues are anticipated to exhibit lucrative growth over the forecast period.
(1984) Prostacyclin and thromboxane synthase as P450 enzymes.
Dileepan, "Increased aortic atherosclerotic plaque development in female apolipoprotein E-null mice is associated with elevated thromboxane A2 and decreased prostacyclin production," Journal of Physiology and Pharmacology : An Official Journal of the Polish Physiological Society, vol.
Peters-Golden, Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2, Journal of Biological Chemistry, 274(17), 11660-11666 (1999).
Effect of curcumin on platelet aggregation and vascular prostacyclin synthesis.
Role of prostacyclin in the cardiovascular response to thromboxane A2.
At other side it proves to be non thrombogenic7,8 because premenopausal women have less chances of developing thromboembolism due to high estrogen than men of same age while post-menopausal females equalizes their risk with males of same age due to low estrogen17 which is also supported by the fact that estrogen has found to maintain vascular health by inducing prostacyclin and nitric oxide synthase through estrogen alpha receptors17,18.
These include the discovery of the vasodilator prostacyclin, that of endothelium-derived relaxing factor and its identification as nitric oxide (NO).
(5) In the CV system, prostacyclin is synthesized by COX-2.
As a member of the prostaglandin family, prostacyclin is released by endothelial cells causing vasodilation and inhibition of platelets (Lowson, 2002).
The ratio between the prostaglandins thromboxane and prostacyclin modulates vascular blood flow, with thromboxane [A.sub.2] acting as a vasoconstrictor and promoting platelet aggregation, while prostacyclin acts as a vasodilator and inhibits aggregation.