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rHuEPORecombinant Human Erythropoietin
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Em virtude da dificuldade de deteccao e diferenciacao entre a rHuEPO e a EPO endogena, bem como do uso da tecnica natural de hipoxia intermitente, que desencadeia aumento da producao de EPO no organismo (Balestra e Germonpre, 2010), este hormonio recombinante passou a ser utilizado de forma indiscriminada por atletas (Magnani e colaboradores, 2001) com o objetivo de melhorar o desempenho fisico (Cazzola, 2002).
Not surprisingly, rHuEPO is amongst the top selling pharmaceutical pro ducts worldwide [7].
It is therefore important to ensure the optimal transportation and storage conditions for specimens being tested for reticulocyte numbers in order to show genuine stimulation of the bone marrow in athletes using rHuEpo (2).
Control of rHuEPO biological activity: the role of carbohydrate.
To accomplish the worldwide demand for recombinant human erythropoietin (rHuEpo) as a therapeutic, application of cost-efficient expression system of methylotrophic yeast Pichia pastoris (P.
Treatment with recombinant erythropoietin (rHuEPO) decreased the transfusion need, and intravenous deferoxamine resulted in a marked decreased in serum ferritin levels and normalization of liver function.
Two major brands of ESAs currently in use in the United States are a recombinant human erythropoietin (rHuEPO) known as epoetin alfa (Procrit, Epogen), and darbepoetin alpha (Aranesp).
(2002): Randomized trial of darbepoetin alfa for treatment of renal anemia at a reduced dose frequency compared with rHuEPO in dialysis patients.
The addition of the sugar chains endows this recombinant protein with a longer serum half-life and sustained erythropoietic activity as compared with conventional recombinant human EPO (rHuEPO) preparations.
The administration of recombinant human erythropoietin (rHuEPO) is another approach.
Sun has patented Fc fusion proteins of human EPO with increased biological activities relative to rHuEPO on a molar basis.
Recombinant human erythropoietin (rHuEPO) [4] is a glycoprotein with 165 amino acids and three N-linked and one O-linked glycans that is expressed in Chinese hamster ovary cells transfected with DNA encoding HuEPO.