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Related to reverse transcriptase inhibitor: NNRTI, NRTI
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References in periodicals archive ?
* NNRTIs (non-nucleoside reverse transcriptase inhibitor) target the same reverse transcriptase enzyme, but do not provide false building blocks.
Other factors associated with severe hepatotoxicity in this study were use of nevirapine-containing drugs, which were associated in those taking a nonnucleoside reverse transcriptase inhibitor with both early (OR 4.00) and late (OR 3.38) severe hepatotoxicity.
BOSTON--HIV-infected patients treated with an antiretroviral regimen that included a nonnucleoside reverse transcriptase inhibitor are less likely to develop primary HIV brain pathology than are those who never received one of these agents, according to an autopsy study.
In addition, patients taking a protease inhibitor were more likely to have hyperglycemia compared to patients taking a non-nucleoside reverse transcriptase inhibitor (NNRTI or "non-nuke").
This is a very active antiretroviral of the NNRTI class (non-nucleoside reverse transcriptase inhibitor -- the same class as efavirenz, nevirapine, and delavirdine, the three NNRTI drugs currently approved in the U.S.).
Biktarvy combines the novel, unboosted integrase strand transfer inhibitor bictegravir, with the demonstrated safety and efficacy profile of the Descovy dual nucleoside reverse transcriptase inhibitor backbone, and is the smallest INSTI-based triple-therapy STR available, the company stated.
If approved, this treatment could be the first two-drug regimen for HIV and could offer those living with HIV who are virally suppressed the option to switch to a regimen which does not include a nucleotide reverse transcriptase inhibitor.
The study also found that HIV patients on a regimen of a protease inhibitor plus a nonnucleoside reverse transcriptase inhibitor had the lowest reductions in total cholesterol and triglycerides of any of the HIV patients.
For example, Tibotec has 2 drugs in parallel development, a protease inhibitor (PI) with good activity against PI-resistant virus and a new non-nucleoside reverse transcriptase inhibitor (NNRTI) that overcomes viral resistance to other drugs of this type.
New precautions have been added to the labeling for Viramune, a non-nucleoside reverse transcriptase inhibitor (NNRTI or "non-nuke").
BARCELONA, SPAIN -- An efavirenz-based regimen became the top choice for the initial treatment of HIV infection based on the results of a study that compared a regimen built on a protease inhibitor with a regimen based on a non-nucleoside reverse transcriptase inhibitor.
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