rhBMP

AcronymDefinition
rhBMPRecombinant Human Bone Morphogenetic Protein
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References in periodicals archive ?
Endplate osteolysis and interbody spacer subsidence are expected in rhBMP assisted fusion.
(1988), attempts to use recombinant human bone morphogenetic proteins (rhBMPs) for bone formation have been performed.
2008 Spine Fusion $1.58B Bone Graft & Bone Substitute Market Allograft $126 DBM $250 Bonegraft Substitutes $800 Machined Bone $100 rhBMP $300 Source: www.pearldiver.com Note: Table made from pie chart.
coli: Escherichia coli FBS: Fetal Bovine Serum FPLC: Fast Protein Liquid Chromatography GRAS: Generally Recognized as Safe GCSF: Granulocyte Colony Stimulating Factor hBMP: human Bone Morphogenetic Protein IPTG: Isopropyl [beta]-D-1-thiogalactopyranoside IL-2: Interleukin 2 IL-3: Interleukin 3 PAGE: Polyacrylamide Gel Electrophoresis pNPP: para-Nitrophenylphosphate rhBMP: Recombinant human Bone Morphogenetic Protein SDS-PAGE: Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis TCA: Trichloroacetic acid TGF[beta]: Transforming Growth Factor beta TMB: 3,3',5,5'-Tetramethylbenzidine.
McGuire, "The use of rhBMP in spine surgery: is there a cancer risk?" Evidence-Based Spine-Care Journal, vol.
rhBMP (monomer) Purification steps Volume Total Purity Recovery (ml) protein (%) (b) (%) (mg) (a) Cultural supernatant 200 90 35 100 Concentrated by freeze 10 89 35 98 drying FPLC 12 1 90 1.12 rhBMP (dimer) Purification steps Volume Total Purity Recovery (ml) protein (%) (b) (%) (mg) (a) Cultural supernatant 200 60 25 100 Concentrated by freeze 5 58 25 96 drying FPLC 7 1.84 80 3.17 (a) Protein concentration was determined by absorbance measurements at [OD.sub.280].
However, the production of the recombinant human Bone Morphogenetic Proteins (rhBMPs) from the mammalian cell cultures has a low production yield and high cost.
Since then, it has been identified 17 different proteins of the same family, that is, proteins with the same characteristics, some of synthesized by molecular biologic techniques, defined as recombinant human morphogenetic proteins or rhBMPs (Wozney, 1989; Celeste et al., 1994; Urist, 1997; Bouxsein et al., 2001).
The development of the recombinant proteins (rhBMPs) began by individual members isolation of the morphogenetic proteins superfamily.
The osteoinductive activity of recombinant human bone morphogenetic proteins (rhBMPs) was analyzed an in vivo studies (Fujimura et al., 1995; Kusumoto et al., 1995).
It has been demonstrated that BMPs in solution are quickly cleared from the body, which may explain why high doses of exogenous rhBMPs are needed for tissue regeneration [16].