rhBMP-2Recombinant Human Bone Morphogenetic Protein Type 2
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A few years later, a well-designed randomized study examined 287 patients with open tibial shaft fractures treated with either the standard of care (reamed intramedullary nail and soft tissue management) or standard of care in addition to rhBMP-2 (1.5 mg/mL, N = 139).
orw/o BMC Rat calvaria Commercially 12 [micro]s 1 defects available pulses, 60 Hz collagen sponges loaded with 2.5-10 [micro]g rhBMP-2 Human adipose Electrospun 50 Hz 1 tissue-derived poly(caprolactone) stem cells nanofibrous scaffolds Experimental PEMF waveform Exposure model Human Trapezoidal 12 hours/ osteosarcoma dayfor 3 days MG-63 cells Primary rat Rectangular 2 or 8 hours/ calvaria day osteoblasts 7F2+ RAW Trapezoidal 9 hours 264.7 Human Trapezoidal 24 osteosarcoma hours/day for Saos-2 cells 22 days Osteochondral Trapezoidal 4 hours/day defects in for 40 days rabbit medial femoral condyles.
In minimally invasive anterior and lateral interbody fusions, a total of 203 patients received DBM in addition to other biologics and achieved a fusion rate of 98% (97-98%), which is significantly higher than any bone graft material (P < 0.05) except for BMA as extender and rhBMP-2 alone for anterior/lateral approach to interbody fusion (Table 2).
When the [OD.sub.600] of the culture reached about 0.6-0.8, the expression of rhBMP-2 was induced by the addition of 1 mM isopropyl-b-D-thiogalactopyranoside (IPTG) for 4h.
Despite the FDA approval of rhBMP-2 for use in anterior cervical discectomy and fusion cases, the FDA issued a warning after several studies encountered prevertebral swelling leading to dysphagia (11, 12).
Por esta razon la concentracion de BMP en el sitio del injerto es mas importante que la dosis total administrada, por lo que la dosis terapeutica sugerida para humanos de rhBMP-2 es de 1,5 mg/ml de suero fisiologico (Davies et al.).
Kim, "Ridge regeneration of damaged extraction sockets using rhBMP-2: An Experimental Study in Canine," Journal of Clinical Periodontology, vol.
Wang, "A composited PEG-silk hydrogel combining with polymeric particles delivering rhBMP-2 for bone regeneration," Materials Science and Engineering C, vol.
Wang et al., "Controlled-release of rhBMP-2 carriers in the regeneration of osteonecrotic bone," Biomaterials, vol.
(17) The future treatment is the use of recombinant human bone morphogenetic protein-2(rhBMP-2) either alone or combination with a bone graft.