JWH and the rhEGF groups were treated according to the above dose by dressing the wound with gauze which was immersed with JWH ointment or immersed with rhEGF, whereas the DC and DNIM groups were treated with a gauze dressing which was only immersed with physiological saline every morning at 9:00 for 21 days.
Yet, on days 14, 21, and 28, the Wagner scores were less in the JWH group and rhEGF group than the DNIM group (P < 0.05 or P < 0.01) as shown in Table 2.
The macroscopic observation results showed that the ulcer treatments were effective in the JWH and rhEGF group.
In the rhEGF group, most of the rats' foot skin was healed with a scar under the subcutaneous tissue; the foot skin structures were clear and flexible.
The wound areas of diabetic rats including the DNIM, JWH, and rhEGF groups were calculated at different times and compared with each other on days 7, 14, 21, and 28.
Jing Wan Hong ointment and rhEGF can increase the mRNA expression of PDGF (F = 29.251, P < 0.05 or P < 0.01).