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As summarized in Table 1, 62 FDG-PET/CT images of 59 patients were reviewed in this retrospective study, as follows: (i) THW group: 21 images; mean age, 61.6 [+ or -] 14.9 years; seven males and 14 females; (ii) rhTSH group: eight images; mean age, 48.4 [+ or -] 14.1 years; four males and four females; (iii) hypothyroidism group: nine images; mean age, 65.8 [+ or -] 17.5 years; four males and five females; (iv) hyperthyroidism group: 14 images; mean age, 50.0 [+ or -] 13.3 years; six males and eight females; and (v) BAT group: 10 images; mean age 52.5 [+ or -] 22.9 years; two males and eight females.
Thyroglobulin measurement in fine-needle aspiration biopsy of metastatic lymph nodes after rhTSH stimulation.
Diagnostic and therapeutic use of recombinant human TSH (rhTSH) in differentiated thyroid cancer.
The rhTSH stimulation test disclosed undetectable serum thyroglobulin and anti-thyroglobulin antibody concentrations in any case.
Therefore, the bone marrow-absorbed dose after treatment with RAI would be expected to be lower for patients given rhTSH, which is protective for hypothyroidism and additionally may reduce the half-life of RAI, than for patients subjected to L-T4 withdrawal (12-14).
Stimulation can be achieved intrinsically via withdrawal of the patient's thyroid hormone replacement medications, or it can be done extrinsically by administration of rhTSH. In addition to the radioiodine scan, standard practice follow-up also usually involves obtaining serum Tg levels and a neck ultrasound scan.
The researchers performed rhTSH testing an average of 6 years after the first control test.
Concerning the effect of acute rhTSH administration on blood pressure, only limited data exist: two studies have not found any association of TSH levels with single blood pressure measurements [15,16].
Botella demonstrated that in women with differentiated thyroid carcinoma, TSH withdrawal results in an increase in leptin concentration.19 However, Cecoli studies on level of leptin at 20 hours after the last rhTSH administration on 15 thyroidectomized patients, showed no regulating role of TSH on leptin concentration.6
Nielsen of Odense (Denmark) University Hospital and colleagues assessed the effect of recombinant human thyrotropin (rhTSH) administered prior to treatment with radioiodine (iodine-131) in patients with nontoxic nodular goiter who were seen at the investigators' outpatient clinic (Arch.
It also suggests that recombinant human TSH (rhTSH) can be used off label to avoid the hypothyroidism of thyroxine withdrawal.
TSH stimulation can be done by either [T.sub.4] withdrawal or recombinant human TSH (rhTSH) administration.
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