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References in periodicals archive ?
The side effect of hepatitis during 2HRZ treatment is attributed to isoniazid, rifampin, and pyrazinamide.
"Higher pretreatment MIC values for either isoniazid or rifampin were associated with an increased risk of relapse, even after accounting for other potential risk factors for relapse," write the authors of an accompanying editorial.
Optimisation of rifampin dosing was considered as a priority because it had the most potent sterilizing effect of the four first-line agents and was available throughout the world.
Use of Genotype MTBDR Assay for Molecular Detection of Rifampin and Isoniazid Resistance in Mycobacterium tuberculosis Clinical Strains Isolated in Italy.
Our patient with atypical mycobacteria was successfully treated with surgical debridement and 6 months of anti-mycobacterial therapy, with 6 months of 2-drug therapy consisting of clarithromycin and rifampin. He had also received 4 months of INH and 2 months of ethambutol, which may not have significantly contributed to his resolution.
In addition, he was initially treated with a combination of INH and rifampin, which has been shown to lead to more rapid development of hepatitis in comparison to INH alone [28].
He had a history of pulmonary TB fourteen years previously that was treated with isoniazid, rifampin, pyrazinamide, and ethambutol for one year.
Risk factors appear to be liver transplantation, use of Rifampin, CMV infection, and the presence of extrapulmonary TB [10].
Group-A patients received the WHO-recommended, dual antimicrobial therapy for brucellosis (doxycycline 200 mg/day and rifampin 900 mg/day, for six weeks).
Rifapentine plus INH had the highest completion rate (88%), significantly exceeding rates for a 4-month course of daily rifampin (84%) and for 9 months of INH monotherapy (70%; P less than .01 for both differences).
(7) For detection of rifampin resistance, the MODS assay is approximately 98% sensitive and 99% specific.