reported an increased serum sVCAM
concentrations in the offspring of T2D patients and elevated levels of sICAM in subjects with IGT or T2D .
A negative and significant (r=-0.155) correlation was found between Magnesium levelsand sVCAM
-1 and CRP (r=-0.051) table-2.
Coronary atherosclerosis causes release of inflammatory cytokines which in turn generate increased expression of CAMS like soluble ICAM-1 and SVCAM
. The mentioned cellular adhesion molecules play a crucial role in the migration of leucocytes from the blood to the arterial intima (transendothelial route).
Additional CPC subsets, CAC numbers, and vascular biomarkers (IL-6, IL-8, TNF[alpha], IP-10, SCF, sSCF-R, VEGF, E-selectin, sICAM, and sVCAM) were determined and compared to AMH as a secondary outcome.
Vascular damage markers sICAM and sVCAM were elevated in patients with DM-1 compared to healthy controls (see Table 2).
We extensively assessed biomarkers in serum samples from this SUDV outbreak and found that IL-10, IP-10, RANTES, sICAM, sVCAM
, and PAI-1 were higher in pediatric patients than in adult patients and were also associated with specific outcomes in pediatric patients.
Thus, monocyte/macrophage accumulation at the lesion site is a key factor in atherosclerotic disease and involves several steps including monocyte recruitment by increased levels of adhesion molecules (sVCAM
, sICAM, E-, and P-selectins) and chemotactic factors (MCP-1, MIP-1[beta], IP-10, and RANTES), the induction of activation, differentiation, and proliferation processes, and immobilization of macrophages in the inflamed plaque .
Measurements of inflammatory factors [Hs-CRP, sE-selectin, sICAM-1, sVCAM
, and interleukin 6 (IL-6)] and flow-mediated dilation (FMD) were made at baseline, 4 hours after first juice consumption and after one month of juice consumption.
To improve precision and run-to-run variability, 1 technician used semiautomated analysis methods on 3 of the markers (sVCAM
, sICAM, CRP), and manual methods were used on the other assayed selectins.
We used RIA (LINGO Research) to measure plasma adiponectin and ELISAs to measure serum concentrations of tumor necrosis factor (TNF) [alpha], IL-6 (R&D Systems Inc.), soluble E-selectin, soluble intercellular adhesion molecule (sICAM) 2, soluble vascular cellular adhesion molecule (sVCAM
) 1, and plasminogen activator inhibitor (PAI) 1 (Bender MedSystems).
 Nonstandard abbreviations: HELLP, hemolysis, elevated liver enzymes, and low platelets; CAM, cell adhesion molecule; sICAM, soluble intercellular adhesion molecule; sVCAM
, soluble vascular cell adhesion molecule; MOM, multiple(s) of the mean; and AUC, area under the curve.
CAD: coronary artery disease, FMD: flow-mediated dilation, GFR: glomerular filtration rate, hsCRP: high-sensitivity C-reactive protein, IL: interleukin, IMT: intimamedia thickness, IRA: infarct-related artery, LDLc: low-density lipoprotein-associated cholesterol, MCAM: melanoma cell adhesion molecule, MCP-1: monocyte chemotactic protein-1, PAI-1: plasminogen activator inhibitor-1, PCOS: polycystic ovary syndrome, sICAM: soluble intercellular adhesion molecule, sVCAM
: soluble vascular cell adhesion molecule, and TD2: type 2 diabetes mellitus.