sVCAM-1Soluble Form of Vascular Cell Adhesion Molecule 1
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In humans, arsenic exposure has been associated with higher circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1) (Chen et al.
Correlation between plasma sICAM-1 sVCAM-1 levels and coronary heart disease QDBS.
To accomplish this, representative circulating endothelial adhesion molecules, and inflammatory markers of sE-selectin, sVCAM-1, TNF-[alpha], Creatine kinase (CK), hs-CRP, and leukocytes were measured at baseline, 100 km, 200 km, and at the end of the 308 km ultra-marathon race.
In the present study, investigated cytokines were intercellular adhesion molecule (ICAM), tumor necrosis factor-[alpha] (TNF-[alpha]), interleukin-6 (IL-6), soluble vascular cell adhesion molecule-1 (sVCAM-1), monocyte chemoattractant protein-1 (MCP-1), and vascular endothelial growth factor (VEGF).
In addition, the MeDiet+nuts group showed lower serum E-selectin levels (P [less than or equal to] 0.02), and the LFD group showed an increase in sVCAM-1 serum levels (P [less than or equal to] 0.03) in both evaluations.
sVCAM-1 (Figure 4(c)) declined in both trials (PLA: 1-2.2-fold, P = 0.000; NAC: 1-2.1-fold, P = 0.000) at all time points measured during recovery with PLA inducing a greater rise (P = 0.016) than NAC on day 2 of recovery.
In addition to ADMA quantification, adhesion molecules, such as sVCAM-1 and soluble intercellular adhesion molecule-1 (sICAM-1) were analyzed using ELISA (Invitrogen, Carlsbad, California, USA).
In addition, overnight fasting blood samples were taken in the morning at baseline and at week 12 to measure the lipid and glucose profiles as well as the concentrations of sVCAM-1 and cGMP.
We measured serum concentration of IL-1[beta], soluble TNF receptors I and II (TNF-RI, TNF-RII), sFas, sFasL, soluble endothelial leukocyte adhesion molecule-1 (sE-selectin), sICAM-1, soluble human vascular cell adhesion molecule-1 (sVCAM-1), MMP-9, TIMP-1, and TGF-[beta]1 using commercially available human Quantikine ELISA Kits (R&D Systems, Minneapolis, USA).
In a study of individuals with diabetes in the Boston area, BC averaged over the previous 24 hr up to 6 days was found to be most strongly associated with increased levels of adhesion molecules involved in inflammation and endothelial function (soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1)] (O'Neill et al.
Multicenter studies that measure the cardiovascular risk markers soluble intracellular adhesion molecules-1 (sICAM-1), soluble vascular cell adhesion molecules-1 (sVCAM-1), soluble (s)E-selectin, sP-selectin, and C-reactive protein (CRP) in serum or plasma require validated procedures for processing, storage, and transport of samples.
The treatment of HCV with IFN-[alpha] and ribavirin did, however, correlate with a significant decrease in TNF receptor-1 and endothelial dysfunction markers, for example, soluble E-selectin and sVCAM-1 [189].