Several investigations suggest that snoRNAs exhibit differential expression in lung tumor and can affect cell transformation, tumorigenesis, and metastasis of NSCLC.
Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs.
Several independent signs of evidence have indicated that these non-coding RNAs might play crucial roles in controlling cell behavior, and snoRNA dysfunction could consequently contribute to oncogenesis in previously unsuspected ways (Williams & Farzaneh, 2012).
Are snoRNAs and snoRNA host genes new players in cancer?
SnoRNAs are divided into two major classes with distinct their signature sequences: box C/D or box H/ACA snoRNAs (Kiss, 2001).
Eddy's group trained its computer bloodhounds to follow the twists and turns of the snoRNA molecule.
Originally designed to analyze languages, they can calculate whether a sequence would fold into the snoRNA structure.
Each of about 60 snoRNAs directs an enzyme to a certain spot on ribosomal RNA, which is a component of the cell's protein-building machinery.
Ding's findings mark the first time that the lack of a distinct type of snoRNA
has been directly linked to a human disease.
snoRNAs represent one of the largest groups of functionally diverse transactivating ncRNAs found in mammalian cells.
snoRNAs and miRNAs are 2 classes of small ncRNAs with diverse functions in RNA modification and posttranscriptional gene silencing (34).
Thereby, we were able to detect new keyplayers, such as snoRNAs and long ncRNAs, which seem to have a more important role in saliva than is currently understood.