"If confirmed, PLT and tHcy
could serve as biomarkers to identify high-risk individuals who would particularly benefit from folic acid treatment," the authors write.
MMA due to methylmalonyl CoA mutate deficiency - normal FA, tHcy
, B12 and methionine; Cb1-RD defects - high tHcy
, low plasma methionine, normal serum B12 and FA;
The analysis of changes in total plasma tHCY
concentration in rabbits demonstrated an increase tendency in a control group and a marked significant increase in both cholesterol-fed groups.
In our case, a LC-MS/MS method for the simultaneous detection of plasma tHcy
, MMA, Met, and 2MCA was implemented.
Increases in both plasma tHcy
and MMA (indicating poorer status) were associated with a decrease in scores on the NEPSY II affect recognition and geometric puzzle subtests.
Elevation of plasma tHcy
is multifactorial: Heritable enzyme deficiencies and vitamin cofactor deficiencies all play a role.
In our study, we observed significantly higher tHcy
levels in umbilical cord blood in newborns with CHD compared to their mothers.
Parameters for metabolic control included plasma levels of fHcy, tHcy
, Met, and Cys.
Several inflammatory biomarkers, such as C-reactive protein (CRP), total homocysteine (tHcy
), tumor necrosis factor receptor 2 (TNFR2), and VEGF, have been found to be associated with an increased risk of ischemic stroke .
A statistically significant increase of mortality risk was found when the level of systolic blood pressure and tHcy
were both taken into account.
The plasma concentrations of total Hcy (tHcy
) were determined with a commercially available immunonephelometric assay (Dade Behring), and the values were expressed in [micro]mol/L.
Among these, high levels of homocysteine (tHcy
) have been proposed as a risk factor for bone alteration and fracture risk also in postmenopausal women , and it has been demonstrated that tHcy
levels increase after menopause in T2DM women as in not diabetic ones .