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References in periodicals archive ?
Castro and Pediatr (2006) stated that Tacrolimus binds with calmodlin by penetrating the membrane of inflamed cells associated with atopic dermatitis and inhibits synthesis of calcineurin in lymphocytes, dentritic cells, basophils and eosinophils, Remitz et al.
While an FDA approved generic tacrolimus is expected to be efficacious, a clinically relevant risk of altered drug exposure may exist when converting patients from one product to another.
The influence of interleukin-10 (IL-10) and interleukin18 (IL-18) polymorphisms on tacrolimus pharmacokinetics had been described in liver and kidney transplantation.
reported complete resolution of LFTA after withdrawal of calcineurin inhibitor (tacrolimus) and replacement with sirolimus.15 It is important to be aware of the possible association of tacrolimus with hepatotoxicity in order to discontinue therapy and replace with sirolimus in cases of hepatotoxicity.
For example, there are several studies looking at the use of Maximum A Posteriori (MAP) Bayesian estimation to predict tacrolimus exposure and subsequent drug dosage requirements in solid organ transplant recipients (3).
All four patients were taking tacrolimus. They are still under the antiepileptic drug treatment.
Major finding: Providers prescribed topical or injected corticosteroids during 61% of visits--far more often than minoxidil (5.9%), topical tacrolimus (5.7%), or other drugs.
Considering that it is his first psychiatric admission, that he has functioned well pre-admission, and that there is no solid evidence to highlight the aetiology of these symptoms, the high level of tacrolimus in the blood stream raises suspicions.
As for refractory AOSD, Murakami and associates reported a case of AOSD with high IL-18 levels in which steroid, MTX, cyclosporin A, infliximab, and etanercept were unsuccessful, but subsequent treatment using tacrolimus in combination with steroid proved successful.
They were given a prescription for 0.1% tacrolimus ointment (Protopic) with instructions to apply it twice daily until their eczema was cleared or almost cleared, then switch to twice-weekly maintenance therapy, shifting back to twice a day therapy as needed to combat flares.
During the treatment with topical tacrolimus, the patient had not reported any side effects such as paraesthesia, burning sensation, itching or skin atrophy associated with tacrolimus as mentioned in literature.
Katsarou et al.9 conducted a randomized controlled trial on thirty patients with hand eczema and compared mometasone furoate with tacrolimus. They did not find any significant difference between the two groups.