1: Reference substances for the development and evaluation of T cell-based assays Substance name CAS# Human Potency Category (1) 2,4-Dinitrochlorobenzene (DNCB) 97-00-7 1 Trinitrobenzene
sulfonic acid (TNBS) 2508-19-2 - 1,4-Phenylenediamine 106-50-3 1 Glyoxal 107-22-2 2 Resorcinol 108-46-3 4 Eugenol 97-53-0 3 Cinnamic alcohol 104-54-1 3 Lactic acid 50-21-5 6 Salicylic acid 69-72-7 6 Glycerol 56-81-5 6 Sodium lauryl sulfate 151-21-3 6 Substance name LLNA Potency Description Category(2) 2,4-Dinitrochlorobenzene (DNCB) Extreme Pos.
Ozawa, "Mechanism and prevention of chronic colonic inflammation with trinitrobenzene
sulfonic acid in rats," Clinical and Experimental Pharmacology and Physiology, vol.
Dietary intervention with green dwarf banana flour (Musa sp AAA) prevents intestinal inflammation in a trinitrobenzene
sulfonic acid model of rat colitis.
Rimkus, "Metabolism of trinitrobenzene
by a Pseudomonas consortium," Canadian Journal of Microbiology, vol.
Altered myoelectrical activity in noninflamed ileum of rats with colitis induced by trinitrobenzene
The target compounds are trinitrotoluene (TNT), trinitrobenzene
(TNB), (N)-trinitro-1, 35% triazacyclohexane (RDX), and other nitrobodies.
Kim, "Inhibitory effects of Geijigajakyak-Tang on trinitrobenzene
sulfonic acid-induced colitis," Journal of Ethnopharmacology, vol.
Stenson, "Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene
sulfonic acid colitis in mice," Gastroenterology, vol.
Sen, "Protective effect of simvastatin and rosuvastatin on trinitrobenzene
sulfonic acid-induced colitis in rats," Indian Journal of Pharmacology, vol.
The prepared supernatant of the hippocampus and cortex was reacted with thiol agents to form trinitrobenzene
at 37[degrees]C; then the reaction mixture was detected at 412 nm.
The peak at 3101 cm -1 and two peaks at 1346 cm -1 and 1557 cm -1 in the IR spectrum of TNPEM (a) could be assigned to trinitrobenzene
ring C-H stretching vibration , antisymmetric stretching vibration peak and symmetric stretching vibration peaks of nitro groups (N=O), respectively[11,12].
In this context, the findings regarding participation of the Th1 response in IBD were reinforced by the fact that colitis induced by trinitrobenzene
sulfonic acid (TNBS) or cell transfer in mice mimics CD and generates an exacerbated Th1 inflammation, with high levels of IL-12, IFN-[gamma], and TNF (57,60,61).