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References in periodicals archive ?
Mesalazine-associated tubulointerstitial nephritis in inflammatory bowel disease.
For 2 patients with granulomatous tubulointerstitial nephritis, 1 had active ulcerative colitis and 1 had fungal forms identified.
The most common diagnosis was diabetic nephropathy (n = 59; 33%) followed by primary and secondary forms of focal segmental glomerular sclerosis (n = 37; 21%), hypertensive and atherosclerotic renal disease (n = 30; 17%), membranous nephropathy (n = 19; 11%), primary chronic tubulointerstitial nephritis (n = 7; 4%), amyloidosis/monoclonal immunoglobulin deposition disease (n = 7; 4%), thin basement membrane nephropathy/Alport syndrome (n = 6; 3%), minimal change disease superimposed on nephrosclerosis (n = 4; 2%), fibrillary glomerulonephritis (n = 3; 2%), inactive membranoproliferative glomerulonephritis or idiopathic nodular glomerular sclerosis (n = 3; 2%), inactive lupus nephritis (n = 1; 1%), and fibronectin glomerulopathy (n = 1; 1%).
The renal parenchymal changes common to all of the above conditions are marked chronic tubulointerstitial nephritis, with disproportionately milder glomerular or vascular changes.
Tubulointerstitial nephritis is a common complication of therapeutic interventions (Table 2), found in up to 25% of all renal biopsies performed for acute renal failure.