u-PA

AcronymDefinition
u-PAurokinase type plasminogen activator
u-PAurinary type plasminogen activator
References in periodicals archive ?
La activacion del plasminogeno por u-PA ocurre preferencialmente en la superficie celular a traves de la union u-PA y plasminogeno a receptores especificos.
Pero existe una significativa diferencia en la expresion de los PA en el FCG de muestras del tejido periodontal con periodontitis, siendo el t-PA encontrado en elevadas concentraciones, inclusive muy superiores a los niveles plasmaticos (5,7,8,9,11,12,13) con valores promedio de 730 ng/ml, que equivale aproximadamente 150 veces los niveles plasmaticos, mientras que la concentracion media del u-PA fue de alrededor de los 100 ng/ml lo que equivale a 500 veces la concentracion plasmatica aproximadamente; pero esta elevada concentracion del u-PA en el FCG en terminos de molaridad equivale a solo el 20 % de la concentracion de t-PA.
Las posibles fuentes del u-PA en el tejido periodontal incluye macrofagos y celulas endoteliales proliferando, que usan el u-PA para su migracion.
Sin embargo, PAI-2 es un inhibidor mas lento para t-PA que para u-PA y no se podria excluir que su funcion tambien pueda ser inhibir las proteasas bacterianas.
Results: There was no difference in serum concentrations of VEGF, NO and u-PA between controls and patients with benign breast disease.
The urokinase typeplasminogen activator (uPA) plays a pivotal role in the regulation of cell adhesion and migration during tissue remodeling, u-PA not only specifically cleaves plasminogen and converts it into plasmin but also activates intracellular signaling upon binding to certain receptors on the cell surface (7).
Serum VEGF and its relationship between NO and u-PA concentration are poorly reported in breast cancer patients.
Serum u-PA concentrations were measured by the quantitative sandwich enzyme immunoassay technique (American Diagnostica u-PA ELISA, USA).
This belief is supported by the fact that in the tissues of tumors of diverse origin t-PA levels are often much lower than in benign tissue, whereas u-PA levels are consistently increased in tumors of diverse origin (De Vries et al.
The aliquots were removed after 24 h incubation and were immediately frozen at -80[degrees]C for later measurement of t-PA, u-PA and PAI-1 (see below).
u-PA antigen in conditioned medium was determined by an ELISA as described by Wojta et al.
The significance of differences in t-PA, u-PA and PAI-1 secretion in response to various oil concentrations was assessed using the Statgraph Program student's two-tailed t-test, with p<0.