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vHNF1Variant Hepatocyte Nuclear Factor 1
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Most recently, insertional mutagenesis in the homeobox gene vhnf1 in zebrafish (equivalent to TCF2-encoded HNF1 b in humans) demonstrated such developmental regulation in an organspecific manner, which involves wt1 and pax2 in the glomerulus and tubules, and more ubiquitous regulators such as shh and pdx1 in the gut.
vhnf1, the MODY5 and familial GCKD-associated gene, regulates regional specification of the zebrafish gut, pronephros, and hindbrain.